Reply: Visually-sensitive networks in essential tremor: evidence from structural and functional imaging
Congratulations Drs. Okun and Wagle Shukla on the publication of “Reply: Visually-sensitive networks in essential tremor: evidence from structural and functional imaging” in the April issue of Brain: A Journal of Neurology.
We thank Tuleasca and colleagues (2018b) for their thoughtful commentary on our manuscript, in which we acutely increased visual feedback and found this exacerbated the amplitude of tremor in patients with essential tremor. Exacerbated tremor was associated with abnormal changes in the blood oxygenation level-dependent (BOLD) signal within the cerebello-thalamo-cortical pathway and extended to visual and parietal areas (Archer et al., 2018). This work is consistent with prior work from our group, which suggested that BOLD amplitude in visual areas was associated with tremor amplitude (Neely et al., 2015). Our findings that visual areas may play a role in the severity of tremor are complimented by several studies by Tuleasca et al. (Tuleasca et al., 2017, 2018a, c). While collectively all of the aforementioned studies point to the idea that there is a widespread functional network related to the amplitude of tremor in essential tremor, one point of departure is whether structural changes exist in essential tremor. To Continue reading click the link above.