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Guangbin Xia, M.D., Ph.D.

Guangbin Xia, M.D., Ph.D.
Assistant Professor

Office Phone: (352) 273-5550
Fax: (352) 273-5575

Clinic Phone:  (352) 265-8408
Fax: (352) 627-4175

Department of Neurology
McKnight Brain Institute
1149 Newell Drive
Gainesville, FL. 32611

Education, Training and Professional Background

M.D. – Second Military Medical University, Shanghai, China
Ph.D. – Tokyo Medical and Dental University, Tokyo, Japan

Intern – University of Virginia
Resident – University of Texas Medical Branch and University of Florida
Fellowship – Neuromuscular Medicine/University of Florida
Trainee – Clinical Research Consortium for Spinocerebellar Ataxias/NIH

Professional Memberships and Certifications

  • Board Certification – American Board of Psychiatry and Neurology
  • Subspecialty Board – Neuromuscular Medicine/ABPN
  • American Academy of Neurology

Research Areas

  1. Induced pluripotent stem cells: Dr. Xia’s research interest is disease-specific induced pluripotent stem (iPS) cell in the application of neurodegenerative disorders. Among them, spinocerebellar ataxias (SCAs) and Myotonic Dystrophy type 1 (DM1) are his current research focus. Dr. Xia is working closely with  Dr. Terada. They have successfully established normal iPS cell lines and disease-specific cell lines for SCA 2, SCA 3 and cell lines for DM1 with long and short pathologic repeats.  They are characterizing the cell lines as disease cellular models. These disease-specific iPS cells will create a platform for the investigation of disease mechanism and drug development.  Correction of mutated gene in iPS cells is challenging but is the critical step for future cell replacement therapy.
  2. Neuropathology: Dr. Xia’s is working on Neuropathology of SCA 10, SCA 3 and Myotonic Dystrophy type in collaboration with Dr.Yachnis on autopsy tissues.
  3. Clinical trials: Dr. Xia’ clinical research interest is therapy of gait incoordination in SCAs. Currently. He is working on a randomized, double-blinded, placebo-controlled, crossover clinical trial of “Therapeutic effect of Dalfampridine on gait incoordination in spinocerebellar ataxias”.

Clinical Practice

Dr. Xia is a board-certified Neurologist and is also board-certified in Neuromuscular Medicine.  He holds hospital privileges for EMG/NCS, muscle biopsy and skin biopsy. His clinical experience includes management of patients with motor neuron diseases, neuropathies, myasthenia gravis, myopathy/muscular dystrophies and other neuromuscular disorders.

Publications on PubMed