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Tetsuo Ashizawa, M.D.

Tetsuo Ashizawa, M.D.
Executive Director, McKnight Brain Institute
The Melvin Greer Professor and Chair of Neurology

Phone: (352) 273-5550
Fax: (352) 273-5575
tetsuo.ashizawa@neurology.ufl.edu

Physical Address:

Room L3-100, McKnight Brain Institute
1149 Newell Drive
Gainesville, FL. 32611

Mailing Address:

Department of Neurology
University of Florida College of Medicine
HSC Box 100236
Gainesville, FL 32610-0236

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Professional Background:

2010-present: Executive Director, Evelyn F. & William L. McKnight Brain Institute at University of Florida
2009-present: Adjunct Professor, UTMB
2009-present: Professor with tenure and Chair, Melvin Greer Professor of Neurology, Department of Neurology, University of Florida, Gainesville, FL
2002-present: Adjunct Professor, BCM
2002-2009: Professor with tenure and Chair, John Sealy Chair of Neurology, Department of Neurology, The University of Texas Medical Branch (UTMB), Galveston, TX
1981-2002: Assistant Professor (1981-1992), Associate Professor with tenure (1992-1997), Professor with tenure (1997-2002), Department of Neurology, BCM
1979-1981: Muscular Dystrophy Association Research Fellowship in Neurochemistry, BCM
1978-1979: Muscular Dystrophy Association Clinical Fellowship in Neuromuscular Disease, BCM
1975-1978: Neurology Residency, Baylor College of Medicine (BCM), Houston, TX (Chief Resident 1978)
1974-1975: Medicine Internship, Allegheny General Hospital, Pittsburgh, PA
1973-1974: Rotating Internship, Yokosuka US Naval Hospital, Yokosuka, Japan, FPO Seattle
1969-1973: M.D., Keio University School of Medicine, Tokyo, Japan (1973)

Personal Info

Dr. Ashizawa completed his Neurology residency training at Baylor College of Medicine where he was appointed Chief Neurology Resident. He then completed fellowship training in Neuromuscular Studies and Neurochemistry with the Muscular Dystrophy Association at Baylor.

Research Interests

Spinocerebellar Ataxia Sub-type 10
Myotonic Dystrophy Type 1
Huntington’s Disease
Friedreich’s Ataxia
Parkinson’s Disease
Myasthenia Gravis

Selected Peer-Reviewed publications (in chronological order)

(Publications selected from 151 peer-reviewed papers, 8 invited editorials, 12 invited reviews, 30 book chapters, 1 book, and 8 electronic journal publications).

  1. Cherng N, Shishkin AA, Schlager LI, Tuck RH, Sloan L, Matera R, Sarkar PS, Ashizawa T, Freudenreich CH, Mirkin SM. Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast. Proc Natl Acad Sci U S A. 2011;108:2843-2848.
  2. White MC, GaoR; Xu W, MandalSM, Lim JG, HazraTK, WakamiyaM, EdwardsSF, RaskinS, TeiveHAG, ZoghbiHY, SarkarPS, Ashizawa T.Inactivation of hnRNP K by Expanded Intronic AUUCU Repeat Induces Apoptosis via Translocation of PKCδ to Mitochondria in Spinocerebellar Ataxia 10. PLoS Genet 2010; 6:e1000984.
  3. Subramony SH, May W, Lynch D, Gomez C, Fischbeck K, Hallett M, Taylor P, Wilson R, Ashizawa T; Cooperative Ataxia Group. Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale. Neurology 2005;64:1261-1262.
  4. Matsuura, T., Yamagata, T., Burgess, D.L., Rasmussen, A., Grewal, R.P., Watase, K., Khajavi, M., McCall, A., Caleb F. Davis, C.F., Zu, L., Achari, M., Pulst, S.M., Alonso, E., Noebels, J.L., Nelson, D.L., Zoghbi, H.Y., Ashizawa, T. Large Expansion of ATTCT Pentanucleotide Repeat in Spinocerebellar Ataxia Type 10. Nat Genet 2000;26:191-194.
  5. Zhuchenko O, Bailey J, Bonnen P, Ashizawa T, Stockton DW, Amos C, Dobyns WB, Subramony SH, Zoghbi HY, Lee CC. Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the ??1A-voltage-dependent calcium channel. Nature Genet 1997;15:62-69
  6. Tokgozoglu LS, Ashizawa T, Pacifico A, Epstein H, Zoghbi WA. Cardiac involvement in a large kindred with myotonic dystrophy:quantitative assessment and relation to expansion of CTG repeats. JAMA 1995;274:813-819.
  7. Ashizawa T, Anvret M, Baiget M, Barceló JM, Brunner H, Cobo AM, Dallapiccola B, Fenwick RG Jr, Grandell U, Harley H, Junien C, Koch MC, Korneluk RG, Lavedan C, Miki T, Mulley JC, López de Munain A, Novelli G, Roses AD, Seltzer WK, Shaw DJ, Smeets H, Sutherland GR, Yamagata H, Harper PS. Characteristics of intergenerational contractions of the CTG repeat in myotonic dystrophy. Am J Hum Genet 1994;54:414-423.
  8. Fu Y-H, Pearlman JA, Pizzuti A, Fenwick RG, Friedman DL, Perryman MB, Richards S, Gibbs RA, Ashizawa T, Scarlato G, Caskey CT. Muscle biochemistry and a genetic study of myotonic dystrophy. Science 1994;264:587-588.
  9. Fu Y-H, Friedman DL, Richards S, Pearlman JA, Gibbs RA, Pizzuti A, Ashizawa T, Perryman MB, Scarlato G, Fenwick RG, Jr, Caskey CT. Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy. Science 1993;260:235-238.
  10. Fu Y-H, Pizzuti A, Fenwick R, King J, Rajnarayan S, Dunne PW, Dubel J, Nasser GA, Ashizawa T, de Jong P, Wieringa B, Korneluk R, Perryman MB, Epstein HF, Caskey CT. An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science 1992;225:1256-1258.