Congratulations Drs., and
The amplitude of high broadband activity (HBA) in human cortical field potentials reflects local processing and has repeatedly been shown to reflect motor control in the primary motor cortex. In a group of male and female subjects affected by essential tremor and undergoing deep brain stimulation surgery, ventral intermediate nucleus (VIM) low frequency oscillations (LFO, <30 Hz) entrain the cortico-motor HBA (>40Hz) during rest, relinquishing that role during movement execution. This finding suggests that there is significant cross-rhythm communication between thalamocortical regions, and motor behavior correspond to changes in thalamocortical phase-amplitude coupling (PAC) profiles. Herein, we demonstrate that thalamocortical coupling is a crucial mechanism for gating motor behavior.