Congratulations to Dr. Nikolaus McFarland on the preprint of “Single-cell multiomics identifies both shared and unique features of immune dysfunction in the colon, plasma and stool from individuals diagnosed with Parkinson’s disease or inflammatory bowel disease.”
Abstract
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease in the world1.Gastrointestinal (GI) dysfunction can occur decades before motor impairments and in up to 80%of individuals living with PD2,3,4. We investigated peripheral relationships that may underliemechanisms along the gut-blood axis that contribute to PD pathogenesis. Single-cell multiomicspatial molecular imaging (SMI) of colonic tissue localized inflammatory injury within epithelialcells that appear to be associated with iron mishandling in both inflammatory bowel disease (IBD)and PD biosamples. We found that both the single-cell SMI of RNA and protein revealed parallelcross-modal dysregulation in the gut epithelium, in both IBD and PD biosamples. These data areaccompanied by plasma (PD) and stool (IBD) protein depletion of CCL22. Our findings suggestiron mishandling along the gut barrier likely contributes to systemic inflammation, which may bethe catalyst that primes circulating immune cells to body-first PD pathogenesis
(PDF) Single-cell multiomics identifies both shared and unique features of immune dysfunction in the colon, plasma and stool from individuals diagnosed with Parkinson’s disease or inflammatory bowel disease.