Cardiac Arrest – POST ICECAP

Name: POST-ICECAP: Patterns Of Survivors’ Recovery Trajectories in the ICECAP trial.

Contact: Dr. John Bruno (PI) and Magali Jorand-Fletcher (Lead CRC) (352) 294-5391

Enrolling hours: Enrollment to Begin Soon

Study Sponsor: NIH

Study Center(s): SIREN Trial Network

Primary Study Objectives:

Describe between-patient variability in the improvement of functional, cognitive, and quality of life outcomes from 3 to 12 months after OHCA.

Secondary Study Objectives:

1. Determine whether changes are associated with illness severity scores and critical care interventions performed during the acute care stay.
2. Determine whether receipt of acute inpatient rehabilitation versus outpatient therapy/no therapy/skilled nursing facility within 1 month of hospital discharge is associated with greater improvement in recovery outcomes from 3 to 12 months.
3. Determine whether non-Hispanic Black and Hispanic/Latinx patients have less favorable changes in recovery outcomes between 3 and 12 months and explore mechanisms for such disparities.

Diagnosis: Cardiac Arrest

Inclusion: 

1. Age > 18 years
2. Coma after resuscitation from OHCA
3. Patients who were either screened or enrolled in the ICECAP trial
4. Received targeted temperature management
5. Participant survived to 1 month
6. Signed ICF by a patient or an authorized representative 

Exclusion: 

1. Neither English nor Spanish speaking
2. Terminal non-cardiovascular illness life expectancy <1 year
3. Hospice as disposition
4. Severe mental illness requiring urgent psychiatric care
5. Pre-existing conditions that could confound outcome determination e.g.,
6. dementia.
7. Known inability to follow up e.g., no reliable phone or internet access