TIA – Sleep Smart

Name: SleepSMART (Sleep for Stroke Management and Recovery Trial) 

Contact: Neringa May (CRC, 352-273-6448) Dr. Anna Khanna (PI) 

Enrolling Hours: M-F (daytime) 

Diagnosis: Ischemic Stroke or High-Risk TIA 


  1. Patients ≥18 years old 
  2. TIA with ABCD2 4 or ischemic stroke within the prior 14 days 
  3. Will remain in hospital long enough to perform OSA testing and CPAP trial night (2 nights) 


  1. CPAP use one month prior to stroke 
  2. Use of oxygen >4L/min 
  3. Pre-event inability to perform all of own basic ADLs  
  4. Unable to obtain informed consent from subject or legally authorized representative  
  5. Incarcerated  
  6. Known pregnancy  
  7. Current mechanical ventilation (can enroll later if this resolves) or tracheostomy  
  8. Anatomical or dermatologic anomaly that makes use of CPAP interface unfeasible  
  9. Severe bullous lung disease  
  10. History of prior spontaneous pneumothorax or current pneumothorax  
  11. Hypotension requiring current treatment with pressors (can enroll later if this resolves)  
  12. Other specific medical circumstances that conceivably, in the opinion of the site PI, could render the patient at risk of harm from use of CPAP  
  13. Massive epistaxis or previous history of massive epistaxis  
  14. Cranial surgery or head trauma within the past 6 months, with known or possible CSF leak or pneumocephalus  
  15. Recent hemicraniectomy or suboccipital craniectomy (i.e. those whose bone has not yet been replaced), or any other recent bone removal procedure for relief of intracranial pressure  
  16. Current contact, droplet, or respiratory/airborne precautions