Demetrius M. Maraganore, MD, FAAN

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Demetrius Michael Maraganore, MD, FAAN is the B.J. and Eve Wilder Professor. His research interests include brain health,  age related memory loss, mild cognitive impairment, dementias and Alzheimer’s disease.  Dr. Maraganore’s passion is helping patients to achieve successful brain aging.  He is inspired by his father’s journey with Alzheimer’s disease (as a caregiver), and by his hundreds of patients with memory loss and dementia.  He is dedicating his career to collaborating with cognitive researchers and clinicians: to develop multidisciplinary brain health programs, and state-wide and national consortia of brain health programs, with the mission of preserving and improving brain health through the primary prevention of cognitive decline, cognitive impairment, dementia, Alzheimer’s disease, and other aging brain disorders.  Dr. Maraganore is committed to achieving these goals at the University of Florida, within the McKnight Brain Institute and the Department of Neurology, and in collaboration with other stakeholder departments and groups across the university.

As the past Chair of Neurology at NorthShore University HealthSystem in Evanston, IL, Dr. Maraganore developed and led the NorthShore Center for Brain Health. He and his team targeted populations at risk for dementia through community outreach and continuing medical education of physicians.  The Center provided outpatient consultations that included risk assessments (of genetic and modifiable factors), personalized interventions (lifestyle, behavioral, and medical), and annual surveillance (early disease detection).  In two years, more than 550 patients were evaluated and managed.  This was one of the first brain health clinics in the United States.

In the Center, Dr. Maraganore and his team also conducted clinical research, including point of care electronic data capture via structured clinical documentation support and clinical decision support tools built into the electronic medical record (EMR).  They developed an Alzheimer’s prediction model using data routinely captured by the EMR.  They biobanked DNAs and plasma.  They genotyped each sample for 1 million single nucleotide polymorphism markers, with the aim of associating genomic variance with brain health measures and outcomes.  His team collaborated to validate a genomic risk score for Alzheimer’s disease.

In addition, Dr. Maraganore supervised the building of structured clinical documentation support and clinical decision support toolkits within the EMR, for the evaluation and management of patients with memory disorders.  These tools supported the clinical practices of neurologists and were also used to support clinical research in cognitive decline, mild cognitive impairment, dementia, and Alzheimer’s disease (medical informatics, biobanking, genomics, biomarkers, comparative effectiveness, and clinical trials).

With Agency for Healthcare Research and Quality funding, the EMR toolkits that Dr. Maraganore built for Brain Health and Memory Disorders practices, as well as for the evaluation and management of other common neurological disorders (11 toolkits and cohorts total), are being shared with 15+ academic departments across the nation, and in return the participating sites are sharing deidentified electronically captured data into a registry, with the aims of quality improvement and practice-based research in neurology using the EMR.  One of the projects includes an EMR-based pragmatic trial comparing the effectiveness of three memory and cognitive enhancing drugs in mild cognitive impairment, which Dr. Maraganore hopes to extend to multiple centers.

At the Mayo Clinic, prior to being Chair of Neurology at NorthShore, and prior to joining the University of Florida, Dr. Maraganore was an internationally recognized expert in Parkinson’s disease, and led the Genetic Epidemiology of Parkinson’s Disease Consortium, that grew to include 60 sites from 30 countries and six continents, and DNAs and data from 85,000 participating human subjects.  He has > 170 peer reviewed full paper publications, and was the principal investigator or co-investigator for research grants > $20 million dollars.

Now focused on successful brain aging, the special skills that Dr. Maraganore brings to the University of Florida are: 1) neurological expertise in aging brain disorders; 2) broad clinical research abilities (including cohort studies, medical informatics, biobanking, genomics, biomarker studies, comparative effectiveness, and clinical trials); 3) a strong record of multidisciplinary collaboration (as the leader of several federally funded grants, and of large national medical informatic and international genetic epidemiological consortia); and 4) administrative experience (including as a Division Chief at the Mayo Clinic and as a Department Chairman at NorthShore).  He is available to see patients at risk for, or with manifest, aging brain disorders; to assist with or lead brain health related community outreach efforts, biobanking initiatives, and clinical research studies; and to develop and collaborate in building University of Florida, state wide, national, and international brain health programs.  He is dedicating half of his effort to clinical practice in seeing at risk and dementia patients, and half of his effort to research and education.  He continues to lead federally funded research studies that he brought from NorthShore to the University of Florida, and he is committed to seeking additional extramural funding.

Medical Education

Northwestern University Medical School; Doctor of Medicine, 1985

Internship

Mayo Graduate School of Medicine; Internal Medicine, 1986

Neurology Residency

Mayo Graduate School of Medicine; Neurology, 1989

Fellowship

Honorary Clinical Research Fellow in Movement Disorders to Professor C.D. Marsden, The National Hospital for Nervous Disorders, Queen Square, London, England, 1990

Clinical Interests

Brain aging (brain health), cognitive decline, mild cognitive impairment, dementia, and Alzheimer’s disease.

Teaching interests

I enjoy working with learners at all levels, and I especially enjoy educating my patients and their families and the community.

Research interests

Quality improvement and practice based research using the electronic medical record (medical informatics), outcome studies that incorporate clinical and genomic data (clinomics), and population level studies that aim to preserve and improve brain health.

Professional Society Memberships

American Academy of Neurology, Member
American Academy of Neurology, Movement Disorders Section, Member
American Academy of Neurology Registry Committee, Member (2015-April 2017)
American Medical Association, Member
Movement Disorders Society, Member

Awards and Recognition

Mayo Foundation Scholarship, 7/89-7/90
Movement Disorders Society, International Executive Committee, Member (by election) 2007-2010
Recipient of the Paul Silverstein Community Service Award for Outstanding Contributions to the Parkinson’s Community 2007
Visiting Professor faculty appointment, University of Milano-Biocca 2009
Team Neurologist, Chicago Bears, 2014-2016
Fellow, American Academy of Neurology, by Board of Directors election, 2015

Selected Publications

Meyers S, Claire Simon K, Bergman-Bock S, Campanella F, Marcus R, Mark A, Freedom T, Rubin S, Semenov I, Lai R, Hillman L, Tideman S, Pham A, Frigerio R, Maraganore DMStructured Clinical Documentation to Improve Quality and Support Practice-Based Research in Headache.  Headache. 2018 Aug 1. doi: 10.1111/head.13348. [Epub ahead of print] PMID: 30066412

Reams N, Anderson J, Perlman R, Li W, Walters S, Tideman S, Wang C, Simon K, Frigerio R, Maraganore DMInvestigating ioflupane I123 injection and single photon emission tomography as an imaging biomarker for long-term sequelae following mild traumatic brain injury.  Brain Inj. 2018;32(1):105-112. doi: 10.1080/02699052.2017.1388443. Epub 2017 Nov 13. PMID: 29131690

Fosnacht AM, Patel S, Yucus C, Pham A, Rasmussen E, Frigerio R, Walters S, Maraganore DFrom Brain Disease to Brain Health: Primary Prevention of Alzheimer’s Disease and Related Disorders in a Health System Using an Electronic Medical Record-Based Approach.  J Prev Alzheimers Dis. 2017;4(3):157-164. doi: 10.14283/jpad.2017.3. PMID: 28856120

Narayanan J, Dobrin S, Choi J, Rubin S, Pham A, Patel V, Frigerio R, Maurer D, Gupta P, Link L, Walters S, Wang C, Ji Y, Maraganore DMStructured clinical documentation in the electronic medical record to improve quality and to support practice-based research in epilepsy.  Epilepsia. 2017 Jan;58(1):68-76. doi: 10.1111/epi.13607. Epub 2016 Nov 19. PMID: 27864833

Maraganore DM, Frigerio R, Kazmi N, Meyers SL, Sefa M, Walters SA, Silverstein JC. Quality improvement and practice-based research in neurology using the electronic medical record. Neurol Clin Pract. 2015 Oct;5(5):419-429. PMID: 26576324

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Contact Information

Demetrius.Maraganore@neurology.ufl.edu

Department of Neurology
Box 100236
Gainesville, FL 32610
(352) 273-5550 (phone)
(352) 273-5575 (fax)