MEG – Magnetoencephalography

Patient in MEG machine

Welcome to the

Magnetoencephalography (MEG) Laboratory at UF Health

As one of approximately 200 MEG centers worldwide – and the only academic MEG center in Florida– our mission is to utilize this advanced technology to serve neurological patients and advance brain science. Our team of clinical experts uses MEG routinely for epilepsy and the planning of epilepsy surgery and brain tumor surgery in both adults and children. We are actively researching applications of MEG to understand movement disorders, dementias, and many other neurological conditions. In collaboration with basic scientists, we are using MEG to explore fundamental questions in the human neuroscience of movement, thought, memory, and consciousness.

At UF Health’s MEG laboratory, innovation and compassion converge to make a difference in the lives of the patients we serve.

What is MEG?

An Introduction to

MEG

Magnetoencephalography (MEG) is entirely non-invasive and the safest known major technology for imaging the human brain.  MEG measures the magnetic fields produced when neurons in the brain communicate with each other. These magnetic fields are extremely small, but MEG sensors are highly sensitive and can pick them up, allowing us to see how different parts of the brain are functioning with millisecond precision in real-time.

The data collected from MEG sensors are combined with magnetic resonance imaging (MRI) to create magnetic source imaging (MSI). MSI provides a dynamic picture of brain activity, helping pinpoint which areas of the brain are involved in specific functions or affected by disorders. This information is crucial for both clinical applications and research purposes.

Patient using MEG

Why is

MEG Useful?

MEG is extremely valuable for both neurological patients as well as for human neuroscience research. In patients with epilepsy and brain tumor, it detects and precisely localizes abnormal neural activity, such as epileptiform discharges, and for maps critical brain functions like speech, movement, sensation, and vision. This detailed mapping is crucial for planning surgery in epilepsy and brain tumors, to avoid damaging essential brain areas while removing abnormal tissue.

As a research tool, MEG provides insight into how the brain processes sensory information, performs motor tasks, and experiences cognition and emotions, and so helps scientists understand the neural basis of various cognitive processes and neurological disorders.

By integrating MEG with other neuroimaging techniques, superior treatment strategies and new scientific discoveries are possible.

MEG

Patient Instructions & Frequently Asked Questions

biomarker MEG

MEG for Epilepsy

MEG plays a crucial role in advanced epilepsy treatments. By measuring the magnetic fields produced by neuronal activity, MEG provides precise localization of epileptiform discharges, which identify regions of the brain where seizures originate. 

MEG Figures MRI of a patient with epilepsy from the left hemisphere showing superimposition of spike and speech localization. The gap between the spikes (yellow triangles) and speech areas (red dots) confirmed that speech function was located at a significant distance away from seizure-producing areas. This allowed brain surgery to be planned that targeted the seizure areas and kept a safe distance from the patient’s speech brain areas.

MEG for Brain Tumor

In brain tumor surgery, MEG helps surgeons to precisely plan and execute operations by distinguishing between tumor tissue and important functional brain areas, such as those responsible for sensory, motor, auditory, visual, and language processing.

The results of MEG functional mapping in a patient with a brain tumor within the upper portion of the middle of the left hemisphere. The blue squares show the brain area identified by MEG as responsible for hand sensation,  the yellow triangle represents the brain area for right lower lip sensation, and the white triangles represent brain areas involved in the hearing of sounds. The tumor was just behind the brain area for left hand sensation. These MEG results provided cautionary information to the neurosurgeon about risk to left hand sensory function while performing tumor removal.

MEG Research

Beyond its established use in epilepsy and brain tumor, researchers are exploring the potential use of MEG in the management of a variety of neurological conditions, such as traumatic brain injury, stroke, and neurodegenerative conditions like Alzheimer and Parkinson disease.

MEG figure MEG localization of spikes in three different clusters in a patient with epilepsy arising from a large portion of one hemisphere