Coralie de Hemptinne, MS, PhD
Assistant Professor
Department:
MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone:
(352) 273-5550
Business Email:
coralie.dehemptinne@neurology.ufl.edu
About Coralie de Hemptinne
Dr. Coralie de Hemptinne is an assistant professor in the Normal Fixel Institute for Neurological Diseases. She earned her B.S degree in Biology from the Universite Libre de Bruxelles and her MS and PhD in Neuroscience from the Universite Catholique de Louvain in Belgium. She worked in Dr. Philip Starr’s laboratory at UCSF as a postdoctoral fellow and then as a research associate from 2010-2020. The current aim of her research is to understand the pathophysiology underlying motor and non-motor symptoms in Parkinson’s disease patients, using invasive chronic, multisite recordings. Her ultimate goal is to develop new neuromodulation strategies for Parkinson’s disease and other movement disorders.
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-2780-3666
Publications
2024
Deep brain stimulation for refractory major depressive disorder: a comprehensive review
Molecular Psychiatry.
[DOI] 10.1038/s41380-023-02394-4.
2024
Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson’s disease.
Brain : a journal of neurology.
[DOI] 10.1093/brain/awae004.
[PMID] 38195196.
2023
Advances in Deep Brain Stimulation: From Mechanisms to Applications.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
43(45):7575-7586
[DOI] 10.1523/JNEUROSCI.1427-23.2023.
[PMID] 37940596.
2023
Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.12.05.570285.
[PMID] 38106063.
2023
Brain Recording Analysis and Visualization Online (BRAVO): An open-source visualization tool for deep brain stimulation data.
Brain stimulation.
16(3):793-797
[DOI] 10.1016/j.brs.2023.04.018.
[PMID] 37100201.
2023
Globus pallidus internus deep brain stimulation evokes resonant neural activity in Parkinson’s disease.
Brain communications.
5(2)
[DOI] 10.1093/braincomms/fcad025.
[PMID] 36895960.
2022
Cortico-Subthalamic Field Potentials Support Classification of the Natural Gait Cycle in Parkinson’s Disease and Reveal Individualized Spectral Signatures.
eNeuro.
9(6)
[DOI] 10.1523/ENEURO.0325-22.2022.
[PMID] 36270803.
2022
Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.
Frontiers in neurology.
13
[DOI] 10.3389/fneur.2022.825178.
[PMID] 35356461.
2022
Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation.
Frontiers in human neuroscience.
16
[DOI] 10.3389/fnhum.2022.1084782.
[PMID] 36819295.
2021
Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience.
15
[DOI] 10.3389/fnhum.2021.765150.
[PMID] 34658825.
2021
Elevated Mood States in Patients With Parkinson’s Disease Treated With Deep Brain Stimulation: Diagnosis and Management Strategies.
The Journal of neuropsychiatry and clinical neurosciences.
33(4):314-320
[DOI] 10.1176/appi.neuropsych.20080205.
[PMID] 34213980.
2021
Image-based biophysical modeling predicts cortical potentials evoked with subthalamic deep brain stimulation.
Brain stimulation.
14(3):549-563
[DOI] 10.1016/j.brs.2021.03.009.
[PMID] 33757931.
2021
Multi-objective data-driven optimization for improving deep brain stimulation in Parkinson’s disease.
Journal of neural engineering.
18(4)
[DOI] 10.1088/1741-2552/abf8ca.
[PMID] 33862604.
2021
Practical Closed-Loop Strategies for Deep Brain Stimulation: Lessons From Chronic Pain.
Frontiers in neuroscience.
15
[DOI] 10.3389/fnins.2021.762097.
[PMID] 34975374.
2021
Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience.
15
[DOI] 10.3389/fnhum.2021.644593.
[PMID] 33953663.
2021
Suppression and Rebound of Pallidal Beta Power: Observation Using a Chronic Sensing DBS Device.
Frontiers in human neuroscience.
15
[DOI] 10.3389/fnhum.2021.749567.
[PMID] 34566612.
2020
Eight cylindrical contact lead recordings in the subthalamic region localize beta oscillations source to the dorsal STN.
Neurobiology of disease.
146
[DOI] 10.1016/j.nbd.2020.105090.
[PMID] 32977021.
2020
Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans.
Neuron.
106(4):579-588.e3
[DOI] 10.1016/j.neuron.2020.02.012.
[PMID] 32155442.
2019
Altered Prefrontal Theta and Gamma Activity during an Emotional Face Processing Task in Parkinson Disease.
Journal of cognitive neuroscience.
31(11):1768-1776
[DOI] 10.1162/jocn_a_01450.
[PMID] 31322465.
2019
Effect of levodopa on electroencephalographic biomarkers of the parkinsonian state.
Journal of neurophysiology.
122(1):290-299
[DOI] 10.1152/jn.00141.2019.
[PMID] 31066605.
2019
Pallidal thermolesion unleashes gamma oscillations in the motor cortex in Parkinson’s disease.
Movement disorders : official journal of the Movement Disorder Society.
34(6):903-911
[DOI] 10.1002/mds.27658.
[PMID] 30868646.
2019
Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling.
Parkinsonism & related disorders.
66:269-271
[DOI] 10.1016/j.parkreldis.2019.08.018.
[PMID] 31477410.
2018
Adaptive deep brain stimulation for Parkinson’s disease using motor cortex sensing.
Journal of neural engineering.
15(4)
[DOI] 10.1088/1741-2552/aabc9b.
[PMID] 29741160.
2018
Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson’s disease.
Journal of neurosurgery.
128(2):605-616
[DOI] 10.3171/2016.11.JNS161162.
[PMID] 28409730.
2018
Cortical gamma oscillations in isolated dystonia.
Parkinsonism & related disorders.
49:104-105
[DOI] 10.1016/j.parkreldis.2018.01.017.
[PMID] 29371063.
2018
Cortical Potentials Evoked by Subthalamic Stimulation Demonstrate a Short Latency Hyperdirect Pathway in Humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
38(43):9129-9141
[DOI] 10.1523/JNEUROSCI.1327-18.2018.
[PMID] 30201770.
2018
Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson’s Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
38(19):4556-4568
[DOI] 10.1523/JNEUROSCI.0431-18.2018.
[PMID] 29661966.
2017
Intraoperative electrocorticography for physiological research in movement disorders: principles and experience in 200 cases.
Journal of neurosurgery.
126(1):122-131
[DOI] 10.3171/2015.11.JNS151341.
[PMID] 26918474.
2017
Neurofeedback Control in Parkinsonian Patients Using Electrocorticography Signals Accessed Wirelessly With a Chronic, Fully Implanted Device.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.
25(10):1715-1724
[DOI] 10.1109/TNSRE.2016.2597243.
[PMID] 28113590.
2017
Nonsinusoidal Beta Oscillations Reflect Cortical Pathophysiology in Parkinson’s Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
37(18):4830-4840
[DOI] 10.1523/JNEUROSCI.2208-16.2017.
[PMID] 28416595.
2017
Subthalamic nucleus deep brain stimulation in isolated dystonia: A 3-year follow-up study.
Neurology.
88(1):25-35
[DOI] 10.1212/WNL.0000000000003451.
[PMID] 27903810.
2016
Electrocorticography reveals beta desynchronization in the basal ganglia-cortical loop during rest tremor in Parkinson’s disease.
Neurobiology of disease.
86:177-86
[DOI] 10.1016/j.nbd.2015.11.023.
[PMID] 26639855.
2016
Gamma Oscillations in the Hyperkinetic State Detected with Chronic Human Brain Recordings in Parkinson’s Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
36(24):6445-58
[DOI] 10.1523/JNEUROSCI.1128-16.2016.
[PMID] 27307233.
2016
Motor System Interactions in the Beta Band Decrease during Loss of Consciousness.
Journal of cognitive neuroscience.
28(1):84-95
[DOI] 10.1162/jocn_a_00884.
[PMID] 26401814.
2016
Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.
Frontiers in neuroscience.
10
[DOI] 10.3389/fnins.2016.00119.
[PMID] 27092042.
2016
Subthalamic local field potentials in Parkinson’s disease and isolated dystonia: An evaluation of potential biomarkers.
Neurobiology of disease.
89:213-22
[DOI] 10.1016/j.nbd.2016.02.015.
[PMID] 26884091.
2015
Elevated synchrony in Parkinson disease detected with electroencephalography.
Annals of neurology.
78(5):742-50
[DOI] 10.1002/ana.24507.
[PMID] 26290353.
2015
Patterns of Cortical Synchronization in Isolated Dystonia Compared With Parkinson Disease.
JAMA neurology.
72(11):1244-51
[DOI] 10.1001/jamaneurol.2015.2561.
[PMID] 26409266.
2015
Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What’s in the Pipeline.
The International journal of neuroscience.
125(7):475-85
[DOI] 10.3109/00207454.2014.999268.
[PMID] 25526555.
2015
Task-related activity in sensorimotor cortex in Parkinson’s disease and essential tremor: changes in beta and gamma bands.
Frontiers in human neuroscience.
9
[DOI] 10.3389/fnhum.2015.00512.
[PMID] 26441609.
2015
Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson’s disease.
Nature neuroscience.
18(5):779-86
[DOI] 10.1038/nn.3997.
[PMID] 25867121.
2014
Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate.
Journal of neural engineering.
11(1)
[DOI] 10.1088/1741-2560/11/1/016009.
[PMID] 24445430.
2014
Effect of frequency on subthalamic nucleus deep brain stimulation in primary dystonia.
Parkinsonism & related disorders.
20(4):432-8
[DOI] 10.1016/j.parkreldis.2013.12.012.
[PMID] 24440061.
2013
Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America.
110(12):4780-5
[DOI] 10.1073/pnas.1214546110.
[PMID] 23471992.
2013
How does Parkinson’s disease and aging affect temporal expectation and the implicit timing of eye movements?
Neuropsychologia.
51(2):340-8
[DOI] 10.1016/j.neuropsychologia.2012.10.001.
[PMID] 23063965.
2012
Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology.
123(11):2232-8
[DOI] 10.1016/j.clinph.2012.04.020.
[PMID] 22633916.
2010
Influence of previous target motion on anticipatory pursuit deceleration.
Experimental brain research.
207(3-4):173-84
[DOI] 10.1007/s00221-010-2437-6.
[PMID] 20963581.
2008
Neuronal bases of directional expectation and anticipatory pursuit.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
28(17):4298-310
[DOI] 10.1523/JNEUROSCI.5678-07.2008.
[PMID] 18434507.
2007
Heterogeneous rate of protein evolution in serotonin genes.
Molecular biology and evolution.
24(12):2707-15
[PMID] 17884826.
2007
How do primates anticipate uncertain future events?
The Journal of neuroscience : the official journal of the Society for Neuroscience.
27(16):4334-41
[PMID] 17442817.
2006
Influence of cognitive expectation on the initiation of anticipatory and visual pursuit eye movements in the rhesus monkey.
Journal of neurophysiology.
95(6):3770-82
[PMID] 16554522.
Grants
Dec 2023
ACTIVE
A retrospective clinical validation of HaGuide software module accuracy in mapping Internal Globus Pallidus (GP) boundaries in Parkinson's disease patients
Role: Principal Investigator
Funding: ALPHA OMEGA ENGINEERING
Jul 2022
– Jun 2023
Directional Globus Pallidus Internus Local Field Potentials as Biomarkers for the Motor Symptoms of Inherited and Idiopathic Dystonia
Role: Other
Funding: DYSTONIA MEDICAL RES FOU
Jun 2022
ACTIVE
Automated selection of deep brain stimulation parameters for Parkinsons Disease Using neurophysiology
Role: Principal Investigator
Funding: PARKINSONS FOU
Apr 2021
– Mar 2024
Fixel Institute Support Fund
Role: Principal Investigator
Funding: UF FOUNDATION
Aug 2020
ACTIVE
Multisite adaptive brain stimulation for multidimensional treatment of refractory chronic pain
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO
via NATL INST OF HLTH NINDS
Aug 2020
– Jun 2023
Technology development for closed-loop deep brain stimulation to treat refractory neuropathic pain
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO
via NATL INST OF HLTH NINDS
Aug 2020
– Jul 2023
Using adaptive deep brain stimulation for gait re-training in Parkinson's Disease
Role: Co-Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO
via FOX FOU, MICHAEL J
Contact Details
Phones:
- Business:
- (352) 273-5550
Emails:
- Business:
- coralie.dehemptinne@neurology.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100268
GAINESVILLE FL 32610 - Business Street:
-
3011 SW WILLISTON RD RM 1103
GAINESVILLE FL 32608