Sridharan Gururangan

Sridharan Gururangan, FRCP

Greene Professor Of Neurosurgery

Department: MD-NEUROLOGICAL SURGERY
Business Phone: (352) 273-9000
Business Email: gururangan@ufl.edu

About Sridharan Gururangan

Sridharan Gururangan, FRCP (Edin.), received his medical degree in 1981 from the University of Madras Chennai, India, proceeded to train in pediatrics in the United Kingdom and eventually became a Member of the Royal College of Physicians, U.K, in 1988. He was subsequently elected to fellowship from the Royal College of Physicians in Edinburgh, U.K. in 2015. He became interested in treating children with cancer during his pediatric training in the U.K. and completed a leukemia research fellowship in Manchester, England. 

Dr. Gururangan moved to the United States in 1991 to pursue his interest in pediatric oncology at St. Jude Children’s Hospital in Memphis, Tenn. and the Memorial Sloan Kettering Cancer Center in New York where he completed his fellowship in pediatric hematology-oncology in 1999. Dr. Gururangan moved to North Carolina to practice at Duke University Medical Center as the director of pediatric neuro-oncology at the Preston Robert Tisch Brain Tumor Center. For 17 years, he treated more than 1,200 children with brain tumors there and led several innovative clinical trials through his interaction with other investigators nationwide. 

Dr. Gururangan joined the UF faculty as an endowed professor in the UF department of neurosurgery in 2016. He also holds a joint appointment in the UF department of pediatrics. He is board certified in pediatric hematology-oncology and neuro-oncology. 

He is passionate about treating children with brain cancer and has been a resource and source of support for countless patients and family members. 

Dr. Gururangan’s research interests are in developing new strategies for treatment of children with brain tumors with a special focus in the development of phase I and II trials of new drugs, including novel chemotherapy agents, small molecule inhibitors targeting receptor tyrosine kinases, anti-angiogenesis inhibitors, pharmacologic strategies that lead to reversal of drug resistance to alkylating agents, immunotherapy approaches to the treatment of recurrent medulloblastoma, and oncolytic viral therapy for neoplastic meningitis. His clinical research has led to more than 100 peer-reviewed publications in prestigious journals, five book chapters and more than 115 abstracts presented at various national and international scientific meetings. 

Dr. Gururangan has earned several awards for his work with pediatric cancer patients, including the Excellence in Pediatric Clinical Research Award from the Society for Neuro-Oncology and two Shining Star Awards from the Make-A-Wish Foundation. Dr. Gururangan is a member of the Pediatric Brain Tumor Consortium and the Children’s Oncology Group.

Board Certifications

  • Neuro-Oncology
    United Council of Neurologic Specialties
  • Pediatric Hematology-Oncology
    American Board of Pediatrics
  • Pediatrics
    American Board of Pediatrics

Clinical Profile

Specialties
  • Pediatrics
Subspecialties
  • Pediatric Hematology-Oncology
Areas of Interest
  • Brain tumor – children
  • Meningitis
  • Neurofibromatosis 2
  • Neurofibromatosis-1
  • Primary lymphoma of the brain

Research Profile

Dr. Gururangan’s research interests are in developing new strategies for treatment of children with brain tumors with a special focus in the development of phase I and II trials of new drugs, including novel chemotherapy agents, small molecule inhibitors targeting receptor tyrosine kinases, anti-angiogenesis inhibitors, pharmacologic strategies that lead to reversal of drug resistance to alkylating agents, immunotherapy approaches to the treatment of recurrent medulloblastoma, and oncolytic viral therapy for neoplastic meningitis. His clinical research has led to more than 100 peer-reviewed publications in prestigious journals, five book chapters and more than 115 abstracts presented at various national and international scientific meetings.

Areas of Interest
  • Cancer Genetics
  • Cell signaling pathways
  • Chemotherapy
  • Drug design
  • Immunotherapy
  • Neuro-Oncology
  • Targeted Cancer Therapy

Grants

Jul 2020 ACTIVE
RNA-nanoparticle vaccines for pediatric high-grade glioma
CURESEARCH FOR CHILDRENS CANCER ·
Dec 2019 ACTIVE
Phase 1 Trial of Marizomib Alone and in Combination with Panobinostat for Children with Diffuse Intrinsic Pontine Glioma
PEDIATRIC BRAIN TUMOR FOUNDATION · Principal Investigator
Nov 2017 ACTIVE
Selective Expansion of Neoantigen-Specific T Cells Targeting Medulloblastoma
THE V FOU FOR CANCER RESEARCH ·
Jul 2017 – Jul 2020
Newly-Diagnosed Brain Stem Gliomas Treated with Adoptive Cellular Therapy During Recovery from Focal Radiotherapy Alone or Radiotherapy and Dose-intensified Temozolomide
THE LYLA NSOULI FOU CHILDRENS BRAIN CANC ·
Jun 2017 – Jun 2020
Newly-Diagnosed Brain Stem Gliomas Treated with Adoptive Cellular Therapy during Recovery from Focal Radiotherapy Alone or Radiotherapy and Dose-intensified Temozolomide
ACCELERATE BRAIN CANCER CURE ·

Education

FRCP
2015 · Royal College of Physicians, Edinburgh, Scotland (Conferred Degree)
Clinical Fellow, Pediatric Hematology/Oncology
1996-1999 · Memorial Sloan Kettering Cancer Center New York, NY
Clinical Fellow, Pediatric Hematology
1996-1999 · New York Hospital, Cornell Medical Center New York, NY
Clinical Fellow, Hematology/Oncology
1993-1994 · St. Jude Children’s Research Hospital Memphis, TN
Senior Resident, Pediatrics
1992-1993 · LeBonheur Children’s Medical Center
Clinical Fellow, Hematology/Oncology
1991-1992 · St. Jude Children’s Research Hospital Memphis, TN
Research Fellow, Pediatric Oncology
1991 · Our Lady’s Hospital for Sick Children Dublin, Republic of Ireland
Senior Resident, Pediatric Oncology
1990 · Our Lady’s Hospital for Sick Children Dublin, Republic of Ireland
Senior Resident, Pediatric Oncology
1988-1989 · Royal Manchester Children’s Hospital Manchester, U.K.
MRCP
1988 · Royal College of Physicians; London, England
Resident, Pediatric Oncology
1988 · Children’s Hospital Sheffield, U.K.
Resident, Pediatrics
1987-1988 · Children’s Hospital Sheffield, U.K.
Resident, Pediatrics
1987 · Royal Victoria Infirmary Newcastle, U.K.
Resident, Neonatal Medicine
1986-1987 · St. Mary’s Hospital Manchester, U.K.
Resident, Pediatrics
1986 · Prince Charles Hospital South Wales, U.K.
Resident, Pediatrics
1985 · Government Stanley Hospital Madras, India
Resident, General Medicine
1984-1985 · Southern Railway Headquarters Hospital Madras, India
Resident, General Medicine
1983-1984 · Government Stanley Hospital Madras, India
Rotating Intern
1982-1983 · Government Stanley Hospital Madras, India
MBBS
1981 · Madras University; Chennai, India
B.Sc. Chemistry
1976 · Loyola College; Madras India

Contact Details

Phones:
Business:
(352) 273-9000
Emails:
Business:
gururangan@ufl.edu