Malú Gámez Tansey
- Mailing Address:
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MCKNIGHT BRAIN INSTITUTE BLDG. LG-152
PO BOX 100244
8989 SW 75TH LANE
GAINESVILLE GA 326100244
Maria de Lourdes (Malú) was born in El Paso, Texas and attended Loretto Academy high school. Dr. Tansey obtained her B.S/M.S in Biological Sciences from Stanford University and her Ph.D. in Cell Regulation from UT Southwestern in Dallas, TX followed by post-doctoral work in neuroscience at Washington University Medical School. Prior to setting up her academic research lab in 2002 at UT Southwestern Medical Center in the Department of Physiology, she was head of the Chemical Genetics group at Xencor, a biotechnology company in Monrovia, working on novel TNF inhibitors that she used as tools in academia to investigate the role of neuroinflammation in neurodegenerative disease and which have now advanced to clinical trials in Alzheimer’s disease and COVID19 for cytokine storm.
After becoming a tenured Associate Professor of Physiology at UT Southwestern in 2008, Dr. Tansey was recruited to Emory University in Atlanta, GA by the Department of Physiology where she became a member of the Center for Neurodegenerative Disease (CND) and also served as Senior Director of Graduate Studies (DGS) for the Emory Neuroscience Graduate Program and a member of the Executive Committee of the Emory Immunology and Molecular Pathogenesis (IMP) Graduate Program. While at Emory, she catalyzed multiple initiatives to expand and coalesce neuroinflammation efforts across the medical school and helped establish the Center for Neurodysfunction and Inflammation (CNI) at Emory in 2018. In 2019, she was recruited to the University of Florida to be Director of the Center for Translational Research in Neurodegenerative Disease (CTRND) and the first endowed Norman and Susan Fixel Chair in Neuroscience and Neurology at the University of Florida.
Today, Tansey’s lab employs multi-disciplinary approaches to investigate the role of inflammation and immune system responses in brain health and the development of neurodegenerative diseases with particular focus on the gut-brain axis . Her long-term goal is to train the next generation of scientists who can/and to develop better therapies to prevent and/or delay these disorders.
As a Hispanic American, Dr. Tansey has served as a role model to numerous undergraduate, graduate and post-graduate trainees, many of them women from under-represented groups in STEM. She served as Co-Director of Emory’s R25 Initiative for Maximizing Student Development (IMSD) whose mission is to strengthen institutional efforts to enhance recruitment and retention of diverse student and faculty bodies at Emory, by providing research training and mentoring opportunities to both. Dr. Tansey is a fierce advocate for women and other under-represented groups in STEM and has earned several mentoring awards from students and faculty for her efforts in this area.
In her spare time, Malú enjoys talking to patient and research-advocacy groups, cooking, sailing, and scuba-diving.
The research interests of our laboratory include investigating the role and regulation of immune and inflammatory mechanisms that protect against or predispose and individual to develop neurodegenerative disorders. Genetic and environmental contributions to lysosomal dysfunction and alterations in lipid signaling that dysregulate neuroimmune activity and trigger neuroinflammation are a main focus of investigation; as is the role of the gut-brain axis and chronic peripheral inflammation in the pathogenesis and progression of neurodegeneration.
- Alzheimer’s Disease
- FTD
- Gut Microbiome
- Microglia
- Neuroimmune interactions in Neurodegenerative diseases
- Neuroinflammation
- Parkinson’s disease
- 2024 Cell Calcium
- 2023 Neurobiology of Disease
- 2023 Nature
- 2023 Frontiers in Cellular Neuroscience
- 2023 Science Translational Medicine
- 2023 Molecular Therapy – Nucleic Acids
- 2023 Alzheimer's & Dementia
- 2022 European Journal of Neuroscience
- 2022 Communications Biology
- 2022 Nature Reviews Immunology
- 2022 Nature Reviews Immunology
- 2022 Molecular Neurodegeneration
- 2022 Movement Disorders
- 2022 Alzheimer's & Dementia
- 2021 npj Parkinson's Disease
- 2021 Molecular Neurodegeneration
- 2021 Molecular Neurodegeneration
- 2021 Scientific Reports
- 2021 Nature Reviews Neurology
- 2021 npj Parkinson's Disease
- 2021 Biological Research For Nursing
- 2021 Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- 2021 Movement Disorders
- 2021 Acta Neuropathologica Communications
- 2021 npj Parkinson's Disease
- 2021 Alzheimer's & Dementia
- 2021 Neuropsychopharmacology
- 2020 Molecular Psychiatry
- 2020 The Journal of Neuroscience
- 2020 Journal of Neuroscience
- 2020 Neurobiology of Disease
- 2020 BioRxiV
- 2020 Frontiers in Immunology
- 2020 Molecules
- 2020 Neurobiology of Disease
- 2020 Movement Disorders
- 2020 Frontiers in Neuroscience
- 2020 eLife
- 2020 Neurobiology of Disease
- 2020 Neuron
- 2020 Scientific Reports
- 2020 Annals of the New York Academy of Sciences
- 2019 Experimental Neurology
- 2019 Alzheimer's research & therapy
- 2019 The Journal of Neuroscience
- 2019 Biochemical Society Transactions
- 2019 Nature
- 2019 Brain, Behavior, and Immunity
- 2019 Brain, Behavior, and Immunity
- 2018 Frontiers in Neuroscience
- 2018 Movement Disorders
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2018
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degenerationJournal of Neuroinflammation
- 2018 European Journal of Neuroscience
- 2018 JAMA Neurology
- 2018 Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- 2017 Neuropsychopharmacology
- 2017 JCI Insight
- 2017 npj Parkinson's Disease
- 2017 Journal of Alzheimer's Disease
- 2017 Neurobiology of Disease
- 2017 Movement Disorders
- 2017 Progress in Neurobiology
- 2017 npj Parkinson's Disease
- 2017 Brain, Behavior, and Immunity
- 2017 Journal of Neuroinflammation
- 2017 Journal of Neuroinflammation
- 2015 npj Parkinson's Disease
- 2014 Journal of Parkinson's Disease
- 2013 Inflammatory Bowel Diseases
- 2013 Journal of Neuroscience
- 2012 Molecular Neurodegeneration
- 2011 Molecular Therapy
- 2009 Neurobiology of Disease
- 2008 Journal of Neuroscience
- 2006 Journal of Neuroscience
- 2003 Science
- Molecular Neurodegeneration
- Molecular Neurodegeneration
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Aug 2024
ACTIVE
Small molecule anti-inflammatory studies in peripheral immune cellsFORWARD THERAPEUTICS · Principal Investigator
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Aug 2024
ACTIVE
Investigating the effects of LRRK2 mutations in immune exhuastionPARKINSONS FOU · Other
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Jun 2024
ACTIVE
Protective activity of XPro1595 against innate immune dysfunction ex vivo -INmune Bio Research Services AgreementINmune Bio, Inc. · Principal Investigator
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Jan 2024
ACTIVE
Weston Family Foundation 2024WESTON FAMILY FOUNDATION · Principal Investigator
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Nov 2023
ACTIVE
Investigation of disease- and pathogen-specific immune dysfunction traits in human PBMCsFOX FOU, MICHAEL J · Principal Investigator
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Jan 2023
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Dec 2023
Weston Family Foundation FY23-24WESTON FAMILY FOUNDATION · Principal Investigator
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Sep 2022
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Aug 2023
Proteins, Pathway, and Pathophysiology in Parkinson's Disease: a Gordon Research ConferenceNATL INST OF HLTH NINDS · Principal Investigator
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Sep 2022
ACTIVE
Tau spreading through the gut-brain axis in a fly model of ADALZHEIMERS ASSO · Co-Investigator
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Aug 2022
ACTIVE
Role of central and peripheral immune crosstalk in FTD-Grn neurodegenerationNATL INST OF HLTH NINDS · Principal Investigator
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Apr 2022
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Dec 2022
Weston Family Foundation FY23WESTON FAMILY FOUNDATION · Principal Investigator
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Apr 2022
ACTIVE
The role of cannabinoid receptor 2 in the clearance of Tau by microgliaALZHEIMERS ASSO · Co-Investigator
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Nov 2021
ACTIVE
Role of enteroendocrine cells in the origin of Parkinson's pathologyDUKE UNIVERSITY · Principal Investigator
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Oct 2021
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Jul 2022
URMC-099 in in vivo AAV-hSYN and in vitro Dopaminergic Neuron ModelsFOX FOU, MICHAEL J · Principal Investigator
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Jul 2021
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Dec 2023
The role of the peripheral immune-system in FTD-GRN; increasing understanding for future therapeutic target developmentBRIGHTFOCUS FOU · Other
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Apr 2021
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Apr 2022
Weston Brain Institute Advisor Award 2021WESTON FAMILY FOUNDATION · Principal Investigator
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Feb 2021
ACTIVE
CTOAUNIV OF FLORIDA · Principal Investigator
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Dec 2020
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Mar 2024
The role of viral infection in immune dysregulation of innate and adaptive immune cells in the prodromal and clinical stages of Parkinsons disease.FOX FOU, MICHAEL J · Principal Investigator
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Sep 2020
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Dec 2023
Validate PFF a-syn induced inflammatory phenotype in mice.FOX FOU, MICHAEL J · Principal Investigator
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Aug 2020
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Apr 2023
Assessing LRRK2, GCase and cytokines in cryopreserved monocytesFOX FOU, MICHAEL J · Principal Investigator
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Jul 2020
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Jul 2021
Weston Brain Institute Grant 2020WESTON BRAIN INSTITUTE · Principal Investigator
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Jul 2020
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Oct 2022
Targeting solTNF-dependent inflammation in ALS with XPro1595 (ALSA)INmune Bio, Inc. · Principal Investigator
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Jun 2020
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Aug 2022
Role of Gut Inflammation and Immunity on Proteostasis, Noradrenergic Degeneration and AD riskNATL INST OF HLTH NIA · Principal Investigator
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May 2020
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Apr 2022
Development of novel viral vectors to study and treat neuroinflammationST JOSEPHS HOSPITAL AND MEDICAL CNTR · Principal Investigator
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Feb 2020
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Sep 2023
The role of cannabinoid receptor 2 in inflammatory responses triggered by alpha-synucleinFOX FOU, MICHAEL J · Co-Project Director/Principal Investigator
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Dec 2019
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May 2024
LRRK2-Synuclein Interactions with Gut Inflammation in PD PathogenesisPARKINSONS FOU · Principal Investigator
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Nov 2019
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Nov 2020
Weston Brain Institute Grant 2019WESTON BRAIN INSTITUTE · Principal Investigator
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Oct 2019
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Oct 2020
Weston Brain Institute GrantWESTON BRAIN INSTITUTE · Principal Investigator
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Oct 2019
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Jul 2024
Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3NORTHWESTERN UNIV · Principal Investigator
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Jul 2019
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Aug 2021
Targeting LRRK2 in models of GI inflammationFOX FOU, MICHAEL J · Principal Investigator
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May 2017
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Jun 2020
Role of HLA/MHCII in Parkinson's Disease PathogenesisEMORY UNIV · Project Manager