Michael A Pizzi

Michael A Pizzi, DO, PhD

Assistant Professor Of Neurology And Neurosurgery, Division Of Neurocritical Care

Business Phone: (352) 273-5550
Business Email: mpizzi@ufl.edu

About Michael A Pizzi

Michael Pizzi, DO, PhD is a board-certified neurologist and neurointensivist. He received his medical degree from Chicago College of Osteopathic Medicine. During medical school Dr. Pizzi was selected for a clinical and research externship at the Rehabilitation Institute of Chicago, where his work on using nanoparticles to facilitate axonal regeneration won the Sarah Baskin award for best research project. Dr. Pizzi completed his internship in internal medicine and neurology residency at the University of Florida-Jacksonville, where he served as chief administrative resident. Dr. Pizzi completed his neurocritical care fellowship at Mayo Clinic Florida, where he received the critical care echocardiography fellow of the year award.

Prior to medical school, Dr. Pizzi earned his MS (Florida State University) and PhD (Medical College of Wisconsin) in neuroscience. Dr. Pizzi’s dissertation research project utilized a novel mechanism by which cancer cells spread in order to facilitate axonal regeneration after traumatic spinal cord injury.

Dr. Pizzi serves on various departmental committees (Co-Chair, Faculty Search Committee, member of Clinical Competency Committee), College of Medicine committee (Therapeutic Temperature Management Committee), and University committee (Chair, Osmotherapy Task Force). He also serves outside the University of Florida as a member of the Society of Critical Care Medicine Scientific Review committee, and member of the editorial board of Critical Care Explorations. He is the co-founder and course director of the Mayo Clinic Neuroscience Convergence meeting, and course director for the Mayo Clinic Neurocritical Care Review Course.

Outside the hospital and lab, he enjoys spending time with his family, scuba diving, and kayaking.


Awarded Faculty Enhancement Opportunity Grant
2021 · University of Florida
Chair, Osmotherapy Task Force
2021 · University of Florida
Co-Chair Faculty Search Committee
2021 · Department of Neurology, University of Florida
Course Director, Deeper Dive in Basic Sciences (DIBS) Seminar
2021 · University of Florida
Member, Therapeutic Temperature Management Committee
2021 · University of Florida
Conducted experiments to Stabilize the blood-brain barrier after acute ischemic stroke
2020 · University of Florida
Member, Clinical Competency Committee
2020 · Department of Neurology, University of Florida
Faculty Golden Apple Award
2018 · Department of Neurology at UF-Jacksonville
Critical Care Echocardiography Fellow of the Year
2017 · Mayo Clinic
Sarah Baskin Award for Excellence in Research
2008 · Department of Physical Medicine and Rehabilitation, Northwestern University
Student Travel Award
2004 · National Neurotrauma Society

Teaching Profile

Courses Taught
MDC7800 Neurology Clerkship

Board Certifications

  • Neurocritical Care
    United Council for Neurologic Subspecialties
  • Neurology
    American Board of Psychiatry and Neurology

Clinical Profile

  • Neurology
Areas of Interest
  • Acute Ischemic Stroke
  • Traumatic Brain Injury

Research Profile

Areas of interest o Preserving the blood-brain barrier after acute brain injury o Characterize the role of the endothelial glycocalyx in regulating cerebral blood flow o Investigating the effects of ketone esters on cerebral blood flow o Developing models to measure brain compliance

Open Researcher and Contributor ID (ORCID)



5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report.
The Neurohospitalist. 12(2):366-370 [DOI] 10.1177/19418744211068913. [PMID] 35419161.
Catch Me If You Can-How Herpes Simplex Virus Tries to Evade Diagnosis in Viral Encephalitis.
Critical care medicine. 50(7):1170-1173 [DOI] 10.1097/CCM.0000000000005501. [PMID] 35726985.
Clinical Challenges of Acute Porphyria in the Young Adult.
The Neurohospitalist. 12(2):377-382 [DOI] 10.1177/19418744211073029. [PMID] 35419127.
Effect of desmopressin acetate on acute spontaneous intracranial hemorrhage in patients on antiplatelet therapy.
Journal of the neurological sciences. 434 [DOI] 10.1016/j.jns.2022.120142. [PMID] 35081458.
Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures.
Neurocritical care. [DOI] 10.1007/s12028-022-01459-6. [PMID] 35217998.
Acute Neurologic Manifestations of Respiratory Viruses.
Continuum (Minneapolis, Minn.). 27(5):1365-1381 [DOI] 10.1212/CON.0000000000001007. [PMID] 34618764.
Pterygopalatine Fossa Blockade as Novel, Narcotic-Sparing Treatment for Headache in Patients with Spontaneous Subarachnoid Hemorrhage.
Neurocritical care. 35(1):241-248 [DOI] 10.1007/s12028-020-01157-1. [PMID] 33403584.
The Modified Early Warning Score: A Useful Marker of Neurological Worsening but Unreliable Predictor of Sepsis in the Neurocritically Ill-A Retrospective Cohort Study.
Critical care explorations. 3(5) [DOI] 10.1097/CCE.0000000000000386. [PMID] 34036267.
Ultrasound of Optic Nerve Sheath Diameter and Stroke Outcomes.
Critical care explorations. 3(11) [DOI] 10.1097/CCE.0000000000000565. [PMID] 34841250.
Factor Xa Inhibitor-Related Intracranial Hemorrhage: Results From a Multicenter, Observational Cohort Receiving Prothrombin Complex Concentrates.
Circulation. 141(21):1681-1689 [DOI] 10.1161/CIRCULATIONAHA.120.045769. [PMID] 32264698.
Intracranial Pressure, More Than a Number?
Critical care medicine. 48(12):e1365-e1366 [DOI] 10.1097/CCM.0000000000004565. [PMID] 33255132.
Adult Presentation of Ornithine Transcarbamylase Deficiency: 2 Illustrative Cases of Phenotypic Variability and Literature Review.
The Neurohospitalist. 9(1):30-36 [DOI] 10.1177/1941874418764817. [PMID] 30671162.
De novo temporal intermittent rhythmic delta activity after laser interstitial thermal therapy for mesial temporal lobe epilepsy predicts poor seizure outcome.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 130(1):122-127 [DOI] 10.1016/j.clinph.2018.11.012. [PMID] 30529878.
Haptoglobin genotype and aneurysmal subarachnoid hemorrhage: Individual patient data analysis.
Neurology. 92(18):e2150-e2164 [DOI] 10.1212/WNL.0000000000007397. [PMID] 30952792.
Investigational drugs for vasospasm after subarachnoid hemorrhage.
Expert opinion on investigational drugs. 27(4):313-324 [DOI] 10.1080/13543784.2018.1460353. [PMID] 29600883.
Post-Intensive Care Unit Cognitive Dysfunction
. 69(1):24-28
A Preliminary Observational Study of Anovulatory Uterine Bleeding After Aneurysmal Subarachnoid Hemorrhage.
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. 49(6):363-371 [DOI] 10.1097/JNN.0000000000000318. [PMID] 29117032.
Ambulance-based assessment of NIH Stroke Scale with telemedicine: A feasibility pilot study.
Journal of telemedicine and telecare. 23(4):476-483 [DOI] 10.1177/1357633X16648490. [PMID] 27177870.
Neurologic Complications of Solid Organ Transplantation.
Neurologic clinics. 35(4):809-823 [DOI] 10.1016/j.ncl.2017.06.013. [PMID] 28962815.
Stroke Diagnosis and Treatment in the Emergency Department.
JAMA neurology. 74(3) [DOI] 10.1001/jamaneurol.2016.5561. [PMID] 28114682.
Transition from intravenous to enteral ketamine for treatment of nonconvulsive status epilepticus.
Journal of intensive care. 5 [DOI] 10.1186/s40560-017-0248-6. [PMID] 28808577.
Update on Neurocritical Care of Stroke.
Current cardiology reports. 19(8) [DOI] 10.1007/s11886-017-0881-7. [PMID] 28646445.
Cerebral Venous Thrombosis Associated with Intracranial Hemorrhage and Timing of Anticoagulation after Hemicraniectomy.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 25(9):2312-6 [DOI] 10.1016/j.jstrokecerebrovasdis.2016.05.025. [PMID] 27321968.
Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia.
Expert review of neurotherapeutics. 16(11):1251-1262 [PMID] 27314601.
Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory.
PloS one. 10(6) [DOI] 10.1371/journal.pone.0131266. [PMID] 26098332.
The societal integration of individuals with epilepsy: perspectives for the 21st century.
Epilepsy & behavior : E&B. 35:42-9 [DOI] 10.1016/j.yebeh.2014.04.006. [PMID] 24798409.
Matrix metalloproteinases and proteoglycans in axonal regeneration.
Experimental neurology. 204(2):496-511 [PMID] 17254568.
Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury.
Experimental neurology. 201(2):335-48 [PMID] 16839548.
Transplantation of fibroblasts that overexpress matrix metalloproteinase-3 into the site of spinal cord injury in rats.
Journal of neurotrauma. 23(12):1750-65 [PMID] 17184186.
Characterization of a chondroitin sultate proteoglycan associated with regeneration in goldfish optic tract.
Neurochemical research. 29(4):719-28 [PMID] 15098933.


Fellowship- Neurocritical Care
2017 · Mayo Clinic
Residency – Neurology
2015 · University of Florida – Jacksonville
Internship – Internal Medicine
2012 · University of Florida – Jacksonville
2011 · Midwestern University
PhD Neuroscience
2006 · Medical College of Wisconsin
MS Neuroscience
2001 · Florida State University
BS Biology
1994 · Northern Illinois University

Contact Details

(352) 273-5550
Business Mailing:
PO Box 100236