Steven N Roper

Steven N Roper, M.D.

PROFESSOR

Department: MD-NEUROLOGICAL SURGERY
Business Phone: (352) 273-9000
Business Email: roper@neurosurgery.ufl.edu

About Steven N Roper

Steven N. Roper, MD, is a professor in the department of neurosurgery and an adjunct professor of neuroscience at the UF College of Medicine.

Dr. Roper graduated summa cum laude with a bachelor of science in biology from Texas A&M University. He then attended medical school at the University of Texas Medical Branch until 1985 and performed his internship and neurosurgical residency at the UCLA School of Medicine. He has received numerous academic honors, including National Merit Scholar and Alpha Omega Alpha.

Dr. Roper joined the faculty of the UF department of neurosurgery in 1992. He serves as the surgical director of the UF Health Comprehensive Epilepsy Program and has performed over 1,500 surgeries for the treatment of epilepsy. He is also the surgical director of the University of Florida Neuroendocrine Program and frequently performs surgeries for pituitary tumors using minimally invasive approaches.

Dr. Roper has received numerous grants, including funding from the Epilepsy Foundation of America, the National Institutes of Health and the McKnight Foundation. These funds support ongoing research in his laboratory, where he and his colleagues are investigating the neurophysiological basis of epilepsy. He has been a member of the board of directors for the American Epilepsy Society since 2009.

Dr. Roper is on the editorial board for the Journal of Neuropathology and Experimental Neurology. He is the author of more than 70 articles and 25 chapters related to various topics on neuroscience. Dr. Roper has also been invited to speak on neuroscience and epilepsy all over the world.

Board Certifications

  • Neurological Surgery
    American Board of Neurological Surgery

Clinical Profile

Specialties
  • Neurosurgery
Areas of Interest
  • Acromegaly
  • Cushing disease
  • Endoscopic skull base surgery
  • Epilepsy
  • Pituitary tumor
  • Prolactinoma
  • Stereotactic radiosurgery

Publications

2021
Inflammatory myofibroblastic tumor masquerading as an anterior choroidal artery fusiform aneurysm.
Surgical neurology international. 12 [DOI] 10.25259/SNI_113_2021. [PMID] 34221627.
2020
Comparing Standard Performance and Outcome Measures in Hospitalized Pituitary Tumor Patients with Secretory versus Nonsecretory Tumors.
World neurosurgery. 135:e510-e519 [DOI] 10.1016/j.wneu.2019.12.059. [PMID] 31863896.
2020
Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.
Neurology. 95(9):e1244-e1256 [DOI] 10.1212/WNL.0000000000010154. [PMID] 32690786.
2019
Two Groups of eGFP-Expressing Neurons with Distinct Characteristics in the Neocortex of GIN Mice.
Neuroscience. 404:268-281 [DOI] 10.1016/j.neuroscience.2019.01.026. [PMID] 30703506.
2017
The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences.
Surgical and radiologic anatomy : SRA. 39(10):1149-1159 [DOI] 10.1007/s00276-017-1843-x. [PMID] 28286911.
2016
Early Life Seizures and Learning Impairment: Neither the Time nor the Place.
EBioMedicine. 7:19-20 [DOI] 10.1016/j.ebiom.2016.05.001. [PMID] 27322452.
2016
Genetic animal models of malformations of cortical development and epilepsy.
Journal of neuroscience methods. 260:73-82 [DOI] 10.1016/j.jneumeth.2015.04.007. [PMID] 25911067.
2016
Long-term Outcome After Fractionated Radiotherapy for Pituitary Adenoma: The Curse of the Secretory Tumor.
American journal of clinical oncology. 39(1):49-54 [DOI] 10.1097/COC.0000000000000014. [PMID] 25007040.
2015
Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice.
PloS one. 10(3) [DOI] 10.1371/journal.pone.0120916. [PMID] 25799505.
2015
Functional integration of human neural precursor cells in mouse cortex.
PloS one. 10(3) [DOI] 10.1371/journal.pone.0120281. [PMID] 25763840.
2014
In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies.
Epilepsia. 55(3):466-7 [DOI] 10.1111/epi.12529. [PMID] 24628654.
2014
Reduced chemical and electrical connections of fast-spiking interneurons in experimental cortical dysplasia.
Journal of neurophysiology. 112(6):1277-90 [DOI] 10.1152/jn.00126.2014. [PMID] 24944214.
2014
TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia.
Journal of neurophysiology. 111(6):1227-37 [DOI] 10.1152/jn.00607.2013. [PMID] 24353305.
2013
Assessing the driving performance of a person with epilepsy presurgery and postsurgery.
The American journal of occupational therapy : official publication of the American Occupational Therapy Association. 67(3):e24-9 [DOI] 10.5014/ajot.2013.006569. [PMID] 23597697.
2013
Cavernoma-related epilepsy: review and recommendations for management–report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies.
Epilepsia. 54(12):2025-35 [DOI] 10.1111/epi.12402. [PMID] 24134485.
2013
Reduced densities of parvalbumin- and somatostatin-expressing interneurons in experimental cortical dysplasia and heterotopia in early postnatal development.
Epilepsy research. 104(3):226-33 [DOI] 10.1016/j.eplepsyres.2012.11.002. [PMID] 23219028.
2013
Stem cells as a potential therapy for epilepsy.
Experimental neurology. 244:59-66 [DOI] 10.1016/j.expneurol.2012.01.004. [PMID] 22265818.
2012
Enhanced hippocampal long-term potentiation and fear memory in Btbd9 mutant mice.
PloS one. 7(4) [DOI] 10.1371/journal.pone.0035518. [PMID] 22536397.
2012
Impaired hippocampal memory function and synaptic plasticity in experimental cortical dysplasia.
Epilepsia. 53(5):850-9 [DOI] 10.1111/j.1528-1167.2012.03431.x. [PMID] 22417090.
2012
Microglial-Neuronal Interactions in the Paraventricular Nucleus (Pvn): a Potential Mechanism Underlying Neurogenic Hypertension
The FASEB's Journal. 26
2012
Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.
Brain research. 1464:61-72 [DOI] 10.1016/j.brainres.2012.04.039. [PMID] 22652067.
2011
Altered behavior in experimental cortical dysplasia.
Epilepsia. 52(12):2293-303 [DOI] 10.1111/j.1528-1167.2011.03267.x. [PMID] 21933180.
2011
Altered firing rates and patterns in interneurons in experimental cortical dysplasia.
Cerebral cortex (New York, N.Y. : 1991). 21(7):1645-58 [DOI] 10.1093/cercor/bhq234. [PMID] 21084454.
2011
Atypical Rasmussen’s encephalitis treated with temporal lobectomy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 18(2):287-90 [DOI] 10.1016/j.jocn.2010.05.011. [PMID] 21163652.
2011
Common data elements in epilepsy research: development and implementation of the NINDS epilepsy CDE project.
Epilepsia. 52(6):1186-91 [DOI] 10.1111/j.1528-1167.2011.03018.x. [PMID] 21426327.
2011
Do subtle cortical structure changes indicate a developmental basis for temporal lobe epilepsy?
Neurology. 76(2):117-8 [DOI] 10.1212/WNL.0b013e318205d545. [PMID] 21148115.
2011
The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission.
Epilepsia. 52(1):158-74 [DOI] 10.1111/j.1528-1167.2010.02777.x. [PMID] 21219302.
2010
Densities of glutamatergic and GABAergic presynaptic terminals are altered in experimental cortical dysplasia.
Epilepsia. 51(8):1468-76 [DOI] 10.1111/j.1528-1167.2010.02583.x. [PMID] 20477846.
2010
Disrupting abnormal electrical activity with deep brain stimulation: is epilepsy the next frontier?
Neurosurgical focus. 29(2) [DOI] 10.3171/2010.4.FOCUS10104. [PMID] 20672924.
2009
Adult Human Neural Progenitor Cells Survive, Migrate, and Differentiate Into Multiple Neuronal Phenotypes in Experimental Cortical Dysplasia
Epilepsia. 50:376-377
2009
Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia.
Journal of neurophysiology. 102(4):2514-25 [DOI] 10.1152/jn.00557.2009. [PMID] 19692507.
2009
Basic mechanisms of MCD in animal models.
Epileptic disorders : international epilepsy journal with videotape. 11(3):206-14 [DOI] 10.1684/epd.2009.0273. [PMID] 19740719.
2009
Developmental Expression of Parvulbumin and Somatostatin in Gabaergic Interneurons in Normal Rodent Cortex and Experimental Cortical Dysplasia
Epilepsia. 50
2009
How Important Is Invasive Ictal Recording in Patients With Itractable Tle and Normal Mri?
Epilepsia. 50
2009
Long-term potentiation of excitatory synapses on neocortical somatostatin-expressing interneurons.
Journal of neurophysiology. 102(6):3251-9 [DOI] 10.1152/jn.00641.2009. [PMID] 19776361.
2009
Seizure recurrence following epilepsy surgery: is post-operative EEG helpful?
Seizure. 18(3):193-6 [DOI] 10.1016/j.seizure.2008.09.003. [PMID] 18948038.
2009
Surgical treatment of the extratemporal epilepsies.
Epilepsia. 50 Suppl 8:69-74 [DOI] 10.1111/j.1528-1167.2009.02239.x. [PMID] 19702737.
2008
4-Aminopyridine Produces Increased Excitability But Decreased Time-Dependent Variability in Excitatory Synaptic Activity in the Neocortex
Epilepsia. 49
2008
Analysis of Epileptiform Activity From Acute Cortical Slice On a 3D 60 Channel Microelectrode Array in Irradiated Rats
Epilepsia. 49:463-464
2008
Enhanced Synaptic Activity in Cortical Interneurons in a Mouse Model of Cortical Dysplasia
Epilepsia. 49
2008
Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography.
Physics in medicine and biology. 53(7):1921-31 [DOI] 10.1088/0031-9155/53/7/008. [PMID] 18364547.
2007
Impaired developmental switch of short-term plasticity in pyramidal cells of dysplastic cortex.
Epilepsia. 48(1):141-8 [PMID] 17241221.
View on: PubMed
2006
A method for a more complete in vitro Parkinson’s model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit.
Journal of neuroscience methods. 157(1):1-9 [PMID] 16704878.
View on: PubMed
2006
Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain.
Development (Cambridge, England). 133(18):3671-81 [PMID] 16914491.
View on: PubMed
2006
Episodic memory in patients with focal frontal lobe lesions.
Cortex; a journal devoted to the study of the nervous system and behavior. 42(8):1080-92 [PMID] 17209414.
View on: PubMed
2006
Reduced excitatory drive in interneurons in an animal model of cortical dysplasia.
Journal of neurophysiology. 96(2):569-78 [PMID] 16641376.
View on: PubMed
2006
Superior divisional third cranial nerve paresis: clinical and anatomical observations of 2 unique cases.
Archives of neurology. 63(5):771-6 [PMID] 16682550.
View on: PubMed
2006
Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America. 103(29):11063-8 [PMID] 16832065.
View on: PubMed
2005
Attentional inhibition in patients with focal frontal lobe lesions.
Journal of clinical and experimental neuropsychology. 27(4):485-503 [PMID] 15962693.
View on: PubMed
2005
Neuron-to-astrocyte transition: phenotypic fluidity and the formation of hybrid asterons in differentiating neurospheres.
The Journal of comparative neurology. 493(3):321-33 [PMID] 16261530.
View on: PubMed
2005
Phenotypic and functional characterization of adult brain neuropoiesis.
Proceedings of the National Academy of Sciences of the United States of America. 102(26):9353-8 [PMID] 15961540.
View on: PubMed
2005
Semantic priming in patients with right frontal lobe lesions.
Journal of the International Neuropsychological Society : JINS. 11(2):132-43 [PMID] 15962701.
View on: PubMed
2004
Cortical dysplasia and epilepsy: animal models.
Advances in experimental medicine and biology. 548:145-74 [PMID] 15250593.
View on: PubMed
2004
Effectiveness of vagus nerve stimulation in epilepsy patients: a 12-year observation.
Neurology. 63(6):1124-6 [PMID] 15452317.
View on: PubMed
2004
The GABAergic system of the developing neocortex has a reduced capacity to recover from in utero injury in experimental cortical dysplasia.
Journal of neuropathology and experimental neurology. 63(12):1265-73 [PMID] 15624763.
View on: PubMed
2004
Tonic activity of metabotropic glutamate receptors is involved in developmental modification of short-term plasticity in the neocortex.
Journal of neurophysiology. 92(2):838-44 [PMID] 15044523.
View on: PubMed
2003
Altered corticogenesis and neuronal morphology in irradiation-induced cortical dysplasia: a Golgi-Cox study.
Journal of neuropathology and experimental neurology. 62(11):1129-43 [PMID] 14656071.
View on: PubMed
2003
Cannabinoid receptor-1 activation suppresses inhibitory synaptic activity in human dentate gyrus.
Neuropharmacology. 45(1):116-21 [PMID] 12814664.
View on: PubMed
2003
PKA and PKC enhance excitatory synaptic transmission in human dentate gyrus.
Journal of neurophysiology. 89(5):2482-8 [PMID] 12611980.
View on: PubMed
2003
Reduction of spontaneous inhibitory synaptic activity in experimental heterotopic gray matter.
Journal of neurophysiology. 89(1):150-8 [PMID] 12522167.
View on: PubMed
2003
Water diffusion measurements in perfused human hippocampal slices undergoing tonicity changes.
Magnetic resonance in medicine. 49(5):856-63 [PMID] 12704768.
View on: PubMed
2002
Category-specific naming deficits for objects and actions: semantic attribute and grammatical role hypotheses.
Neuropsychologia. 40(9):1608-21 [PMID] 11985843.
View on: PubMed
2002
Cortical dysgenesis and epilepsy.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 8(4):356-71 [PMID] 12194504.
View on: PubMed
2002
MMPI-2 profiles of patients with intractable epilepsy.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 17(6):583-93 [PMID] 14591857.
View on: PubMed
2001
An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability.
The European journal of neuroscience. 14(2):203-9 [PMID] 11553273.
View on: PubMed
2001
Brain-derived neurotrophic factor enhances fast excitatory synaptic transmission in human epileptic dentate gyrus.
Annals of neurology. 50(2):188-94 [PMID] 11506401.
View on: PubMed
2001
Lateralization of temporal lobe foci: depth versus subdural electrodes.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 112(5):836-44 [PMID] 11336899.
View on: PubMed
2001
The role of the frontal lobes in memory: evidence from unilateral frontal resections for relief of intractable epilepsy.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 16(6):571-85 [PMID] 14590155.
View on: PubMed
2000
Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy.
The Journal of comparative neurology. 418(4):411-22 [PMID] 10713570.
View on: PubMed
2000
Bcl-2 immunoreactive cells with immature neuronal phenotype exist in the nonepileptic adult human brain.
Journal of neuropathology and experimental neurology. 59(2):113-9 [PMID] 10749100.
View on: PubMed
2000
Electroencephalographic, volumetric, and neuropsychological indicators of seizure focus lateralization in temporal lobe epilepsy.
Archives of neurology. 57(5):707-12 [PMID] 10815137.
View on: PubMed
2000
Reduced inhibition in an animal model of cortical dysplasia.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(23):8925-31 [PMID] 11102503.
View on: PubMed
1999
Conduction aphasia and the arcuate fasciculus: A reexamination of the Wernicke-Geschwind model.
Brain and language. 70(1):1-12 [PMID] 10534369.
View on: PubMed
1999
Electrophysiological responses in vivo of hippocampal CA1 pyramidal neurons in an animal model of neuronal migration disorders.
Developmental neuroscience. 21(3-5):374-84 [PMID] 10575261.
View on: PubMed
1999
Reduced density of parvalbumin- and calbindin D28-immunoreactive neurons in experimental cortical dysplasia.
Epilepsy research. 37(1):63-71 [PMID] 10515176.
View on: PubMed
1999
Synaptic responses of neurons in heterotopic gray matter in an animal model of cortical dysgenesis.
Developmental neuroscience. 21(3-5):365-73 [PMID] 10575260.
View on: PubMed
1998
In utero irradiation of rats as a model of human cerebrocortical dysgenesis: a review.
Epilepsy research. 32(1-2):63-74 [PMID] 9761309.
View on: PubMed
1998
In vivo detection of experimentally induced cortical dysgenesis in the adult rat neocortex using optical coherence tomography.
Journal of neuroscience methods. 80(1):91-8 [PMID] 9606054.
View on: PubMed
1998
Tuberous sclerosis-related gene expression in normal and dysplastic brain.
Epilepsy research. 32(1-2):12-23 [PMID] 9761305.
View on: PubMed
1997
Disinhibited in vitro neocortical slices containing experimentally induced cortical dysplasia demonstrate hyperexcitability.
Epilepsy research. 26(3):443-9 [PMID] 9127725.
View on: PubMed
1997
Exposure to in utero irradiation produces disruption of radial glia in rats.
Developmental neuroscience. 19(6):521-8 [PMID] 9445089.
View on: PubMed
1997
Invasive monitoring of limbic epilepsy using stereotactic depth and subdural strip electrodes: surgical technique.
Surgical neurology. 48(1):74-9 [PMID] 9199690.
View on: PubMed
1997
Non-linearity in invasive EEG recordings from patients with temporal lobe epilepsy.
Electroencephalography and clinical neurophysiology. 102(2):98-105 [PMID] 9060860.
View on: PubMed
1997
White matter neuronal heterotopia in temporal lobe epilepsy: a morphometric and immunohistochemical study.
Journal of neuropathology and experimental neurology. 56(12):1276-82 [PMID] 9413276.
View on: PubMed
1996
Intractable temporal lobe epilepsy: comparison of positron emission tomography with qualitative and quantitative MR.
AJNR. American journal of neuroradiology. 17(8):1515-21 [PMID] 8883651.
View on: PubMed
1996
Prospective localization of epileptogenic foci: comparison of PET and SPECT with site of surgery and clinical outcome.
Radiology. 199(2):375-80 [PMID] 8668781.
View on: PubMed
1996
Quantified volumes of temporal lobe structures in patients with epilepsy.
Journal of neuroimaging : official journal of the American Society of Neuroimaging. 6(2):108-14 [PMID] 8634483.
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1996
The taste of monosodium glutamate: membrane receptors in taste buds.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 16(12):3817-26 [PMID] 8656276.
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1995
Experimentally induced disorders of neuronal migration produce an increased propensity for electrographic seizures in rats.
Epilepsy research. 21(3):205-19 [PMID] 8536674.
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1995
Hippocampal volumetrics differentiate patients with temporal lobe epilepsy and extratemporal lobe epilepsy.
Archives of neurology. 52(8):819-24 [PMID] 7639634.
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1994
Ca(2+)-dependent Cl- conductance in taste cells from Necturus.
Journal of neurophysiology. 72(1):475-8 [PMID] 7965031.
View on: PubMed
1993
Increased propensity for nonsynaptic epileptiform activity in immature rat hippocampus and dentate gyrus.
Journal of neurophysiology. 70(2):857-62 [PMID] 8410177.
View on: PubMed
1993
Surgery for epilepsy. Special pediatric considerations.
Neurosurgery clinics of North America. 4(2):301-10 [PMID] 8467216.
View on: PubMed
1993
Surgical anatomy of the temporal lobe.
Neurosurgery clinics of North America. 4(2):223-31 [PMID] 8467209.
View on: PubMed
1993
Surgical treatment of partial epilepsy arising from the insular cortex. Report of two cases.
Journal of neurosurgery. 79(2):266-9 [PMID] 8331411.
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1992
Osmolality and nonsynaptic epileptiform bursts in rat CA1 and dentate gyrus.
Annals of neurology. 31(1):81-5 [PMID] 1543352.
View on: PubMed
1991
An analysis of cerebral blood flow in acute closed-head injury using technetium-99m-HMPAO SPECT and computed tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 32(9):1684-7 [PMID] 1880569.
View on: PubMed
1987
Neonatal synapse elimination in the rat submandibular ganglion: effect of retarded target growth.
Journal of neurophysiology. 58(2):288-99 [PMID] 3655868.
View on: PubMed
1987
Retrograde effects of target atrophy on submandibular ganglion neurons.
Journal of neurophysiology. 58(2):276-87 [PMID] 3655867.
View on: PubMed
1984
On the two subdivisions and intrinsic synaptic connexions in the submandibular ganglion of the rat.
The Journal of physiology. 346:301-20 [PMID] 6142105.
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1982
Reinnervation of the amphibian cardiac ganglion after complete or partial denervation.
The Journal of physiology. 333:157-72 [PMID] 6985072.
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1978
Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization.
Science (New York, N.Y.). 202(4363):66-8 [PMID] 308697.
View on: PubMed
1976
An electrophysiological study of chemical and electrical synapses on neurones in the parasympathetic cardiac ganglion of the mudpuppy, Necturus maculosus: evidence for intrinsic ganglionic innervation.
The Journal of physiology. 254(2):427-54 [PMID] 175154.
View on: PubMed
1976
Synaptic organization and acetylcholine sensitivity of multiply innervated autonomic ganglion cells.
Cold Spring Harbor symposia on quantitative biology. 40:283-95 [PMID] 181198.
View on: PubMed

Grants

Apr 2009 – Apr 2021
Implantation of Adult Human Neural Progenitors into an Amimal Model fo Cortical Dysplasia
Role: Principal Investigator
Funding: UF FOU
Aug 2008 – Apr 2021
Wells Professorship
Role: Principal Investigator
Funding: UF FOU

Education

Residency – Surgery
1987 · UCLA Medical Center
Internship – Surgery
1986 · UCLA Medical Center
Medical Degree
1985 · University of Texas
Residency – Neurological Surgery
1982 · UCLA Medical Center

Teaching Profile

Courses Taught
2018
MDC7600 Surgery Clerkship
2018
MDT7650 Elect Top/Neurol Surg

Contact Details

Phones:
Business:
(352) 273-9000
Emails: