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UF Health University of Florida
Department of Neurology College of Medicine
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Kyle W Ruffing

Kyle W Ruffing, MD, FAAN

Assistant Professor; Director, Neuromuscular Fellowship Program

Department: MD-NEUROMUSCULAR NEUROLOGY
Business Phone: (352) 294-5000
Business Email: kruffing@ufl.edu

On This Page

About Kyle W Ruffing

I’m Dr. Kyle Ruffing, and I joined the UF Health team in November 2022.

I obtained both my undergraduate degree and medical degree here at the University of Florida, where I was a member of the UF Junior Honors Medical Program. Following graduation in 1993, I traveled to the University of Michigan in Ann Arbor to complete an internship, neurology residency, and fellowship in neuromuscular disorders and electromyography.

Before joining the team at UF Health, I practiced neurology and neuromuscular medicine in beautiful Sarasota, Florida.

I am board certified in neurology, electromyography and neuromuscular medicine.

Teaching Profile

Courses Taught

  1. MDC7800 – Neurology Clerkship

    College of Medicine

Board Certifications

  • Neurologist
    American Board of Psychiatry and Neurology
  • Neurologist
    American Board of Electrodiagnostic Medicine

Clinical Profile

Neurology and Neuromuscular Medicine

Specialties

  • Neuromuscular Medicine

Areas of Interest

  • Adult muscular dystrophy
  • Chronic Inflammatory Demyelinating Polyneuropathy
  • Electromyography
  • Myasthenia Gravis
  • Nerve Conduction Velocity
  • Neuromuscular Disorders
  • Peripheral Neuropathy

Research Profile

Areas of Interest

  • Becker Muscular Dystrophy
  • Facioscapulohumeral dystrophy
  • Muscular dystrophy
  • Myotonic Dystrophy
  • Neuromuscular Diseases
  • Neuromuscular junction
  • Neuropathy

Publications

Academic Articles

  1. Force-based manipulation via wearable focal vibration for pain relief and changes in gait biomechanics in diabetic peripheral neuropathy: a secondary analysis of a pilot trial.

    Journal
    Frontiers in pain research (Lausanne, Switzerland).
    Volume/Issue
    7
    [DOI]
    10.3389/fpain.2026.1925489.
    [PMID]
    42638812.
    PubMed Publisher’s Site

  2. Clinical Reasoning: A 55-Year-Old Man With Rapidly Progressive Weakness and Numbness.

    Journal
    Neurology.
    Volume/Issue
    106(11)
    [DOI]
    10.1212/WNL.0000000000218063.
    [PMID]
    42127357.
    PubMed Publisher’s Site

  3. Paucibacillary leprosy presenting as fibular neuropathy: A case of autochthonous zoonotic exposure in endemic Florida.

    Journal
    PLoS neglected tropical diseases.
    Volume/Issue
    20(6)
    [DOI]
    10.1371/journal.pntd.0014456.
    [PMID]
    42330030.
    PubMed Publisher’s Site

  4. Novel FHL1 Mutation Associated With Reducing Body Myopathy.

    Journal
    Cureus.
    Volume/Issue
    18(5)
    [DOI]
    10.7759/cureus.109269.
    [PMID]
    42326197.
    PubMed Publisher’s Site

  5. Head trauma and environment progression of amyotrophic lateral sclerosis: long-term data from the National ALS Registry.

    Journal
    BMJ neurology open.
    Volume/Issue
    8(1)
    [DOI]
    10.1136/bmjno-2026-001574.
    [PMID]
    42093834.
    1 citation PubMed Publisher’s Site

Grants

  1. An Open-Label Extension Study to Assess the Long-term Effect of EDG-5506 on Safety, Biomarkers, and Functional Measures in Adults and Adolescents with Becker Muscular Dystrophy

    Active

    Role:
    Principal Investigator
    Funding:
    EDGEWISE THERAPEUTICS

  2. 214 CTOA: Ruffing

    Active

    Role:
    Principal Investigator
    Funding:
    UNIV OF FLORIDA

  3. Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Muscular Dystrophy

    Active

    Role:
    Principal Investigator
    Funding:
    EDGEWISE THERAPEUTICS

Education

  1. Fellowship – EMG and Neuromuscular Disorders

    University of Michigan Medicine Department of Neurology, Ann Arbor, Michigan

  2. Residency – Neurology

    University of Michigan, Department of Neurology, Ann Arbor, Michigan

  3. MD

    University of Florida College of Medicine, Gainesville, Florida

  4. BS -Interdisciplinary Biological and Medical Science,Junior Honors Program (Medical Honors Program)

    University of Florida, Gainesville, FL

Contact Details

Phones:
Business:
(352) 294-5000
Emails:
Business:
kruffing@ufl.edu
Addresses:
Business Mailing:
G387 PSB
 GAINESVILLE FL 32611
Business Street:
1600 SW ARCHER RD
 GAINESVILLE FL 32610