Robert C Sharp

Robert C Sharp, PhD

Cell Culture Biologist

Department: MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone: (352) 273-9300
Business Email: rsharp07@ufl.edu

About Robert C Sharp

Robert C. Sharp, Ph.D., has joined Professor Matthew Farrer’s Laboratory of Neurogenetics and Neuroscience as a Cell Culture Biologist (Biological Scientist II). He is working with the Farrer lab on their studies on the role of the leucine-rich repeat kinase 2 (LRRK2) protein in Parkinson’s disease pathogenesis. With his expertise in cell line and primary cell culturing, immunocytochemistry, flow cytometric immunophenotyping, gene editing, and overall molecular/cell biology, he provides support and new ideas for the Farrer lab.

As a clinical immunologist, Dr. Sharp has studied various of autoimmune diseases throughout his Bachelor’s (Biotechnology, University of Central Florida, 2013), his Master’s (Biomedical Sciences, University of Central Florida, 2014), his Ph.D. (Biomedical Sciences, University of Central Florida, 2018), and his postdoctoral career (University of Florida Diabetes Institute, 2019-2022). These autoimmune diseases include: Crohn’s disease, rheumatoid arthritis, ulcerative colitis, and type 1 diabetes. As such, he hope that while working with the Farrer lab, to find the connection of LRRK2 to both neurological and immunological diseases.

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-5167-8941

Publications

2022
Modeling human T1D-associated autoimmune processes.
Molecular metabolism. 56 [DOI] 10.1016/j.molmet.2021.101417. [PMID] 34902607.
2021
De-coding genetic risk variants in type 1 diabetes.
Immunology and cell biology. 99(5):496-508 [DOI] 10.1111/imcb.12438. [PMID] 33483996.
2021
The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.739048. [PMID] 34603322.
2019
Polymorphisms in TNF Receptor Superfamily 1B (TNFRSF1B:rs3397) are Linked to Mycobacterium avium paratuberculosis Infection and Osteoporosis in Rheumatoid Arthritis
Microorganisms. 7(12) [DOI] 10.3390/microorganisms7120646. [PMID] 31817071.
2018
Development of multiplex PCR and multi-color fluorescent in situ hybridization (m-FISH) coupled protocol for detection and imaging of multi-pathogens involved in inflammatory bowel disease.
Gut pathogens. 10 [DOI] 10.1186/s13099-018-0278-1. [PMID] 30534203.
2018
Polymorphisms in Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22) Are Linked to Hyper-Proliferative T-Cells and Susceptibility to Mycobacteria in Rheumatoid Arthritis.
Frontiers in cellular and infection microbiology. 8 [DOI] 10.3389/fcimb.2018.00011. [PMID] 29423382.
2018
Role of PTPN2/22 polymorphisms in pathophysiology of Crohn’s disease.
World journal of gastroenterology. 24(6):657-670 [DOI] 10.3748/wjg.v24.i6.657. [PMID] 29456405.
2018
Systematic review and meta-analysis on the association of tuberculosis in Crohn’s disease patients treated with tumor necrosis factor-α inhibitors (Anti-TNFα).
World journal of gastroenterology. 24(25):2764-2775 [DOI] 10.3748/wjg.v24.i25.2764. [PMID] 29991880.
2015
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn’s Disease.
Frontiers in cellular and infection microbiology. 5 [DOI] 10.3389/fcimb.2015.00095. [PMID] 26734582.

Grants

Apr 2021 – Jun 2022
Human Islet Research Enhancement Center for the Human Islet Research Network: "The SIRP:CD47 Signaling Pathway in Pancreatic ?-Cell Survival"
Role: Principal Investigator
Funding: CITY OF HOPE via NATL INST OF HLTH NIDDK

Contact Details

Phones:
Business:
(352) 273-9300
Emails:
Business:
rsharp07@ufl.edu
Addresses:
Business Mailing:
PO Box 100236
GAINESVILLE FL 32610
Business Street:
1149 NEWELL DR RM L1 151
GAINESVILLE FL 32610