Alexis N Simpkins

Alexis N Simpkins, MD, PhD, MSCR, FAHA

Clinical Assistant Professor

Department: MD – VASCULAR NEUROLOGY
Business Phone: (352) 273-5550

About Alexis N Simpkins

Alexis Nétis Simpkins, MD, PhD, MSCR, FAHA is an Assistant Professor of neurology in the University of Florida College of Medicine. Dr. Simpkins first earned a bachelor of science degree in chemistry, along with a minor in biology, at Augusta University in Georgia. She was then accepted into the dual doctoral program at the Medical College of Georgia in Augusta, obtaining her medical doctoral degree and a doctorate in vascular biology after investigating utility of a novel agent in vascular and neuroprotection in hypertension and stroke.

She completed her internal medicine internship at the Medical College of Georgia in Augusta. Next, she completed a neurology residency at The Johns Hopkins Hospital in Baltimore. Dr. Simpkins completed her time in Maryland with a combined clinical and research vascular neurology fellowship at the National Institute of Neurological Disorders and Stroke.

Dr. Simpkins is an active member in the American Heart Association and Director of the CREST Initiative for stroke trainee and fellow research and career development in the Vascular Neurology Division.

Accomplishments

College of Medicine Exemplary Teacher Award
2021 · University of Florida
Fellow, American Heart Association
2020 · AHA
HEADSUP Junior Investigator Travel Award
2020 · American Heart Association, International Stroke Conference
Named one of the 1,000 Inspiring Black Scientists in America by The Community of Scholars, in the Cell Press Blog
2020 · America by The Community of Scholars, in the Cell Press Blog
Best Poster Award at the International Genetics Consortium
2019 · International Stroke Genetics Consortium
Recognized at top 10% abstract from International Stroke Conference for abstract “Secondary Stroke Prevention with Aspirin and Clopidogrel in CYP2C19*17 Carriers Increases Risk of Major Non-CNS Bleeding” of 2019
2019 · American Heart Association
TRANSCENDS Scholar
2017 · American Academy of Neurology
First prize winner of the Stroke Progress and Innovation Award
2016 · Stroke (medical journal)
VA Chief of Neurology Award
2009 · Medical College of Georgia

Teaching Profile

Courses Taught
2020-2021
PHA6613 Clinical Applications Precision Medicine: Precision Health
2021
MDC7800 Neurology Clerkship

Board Certifications

  • ABPN Neurology Boards
    Neurology
  • ABPN Vascular Neurology Boards
    Vascular Neurology

Clinical Profile

Specialties
  • Neurology
Areas of Interest
  • Acute Ischemic Stroke
  • Stroke

Research Profile

Areas of Interest
  • Advanced MRI and stroke
  • Blood biomarkers and stroke
  • Monitoring and evaluating stroke therapy
  • Protective and preventive measures of cerebrovascular disorders (cerebral ischemia, vascular remodeling and neurological imaging)
  • Stroke recovery
Open Researcher and Contributor ID (ORCID)

0000-0001-7529-4267

Publications

2022
Apparent Treatment-Resistant Hypertension Among Stroke Survivors: A Transcontinental Study Assessing Impact of Race and Geography
American Journal of Hypertension. [DOI] 10.1093/ajh/hpac046.
2022
Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study
Stroke. 53(3):728-738 [DOI] 10.1161/strokeaha.121.037541.
2022
Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality.
Journal of stroke. 24(2):256-265 [DOI] 10.5853/jos.2022.00752. [PMID] 35677980.
2022
Risk of Acute Ischemic Stroke in Patients 65 and Older Is Early After COVID-19 Diagnosis.
Neurology. 98(8):301-302 [DOI] 10.1212/WNL.0000000000013182. [PMID] 35115386.
2022
The Importance of Incorporating Stroke Survivors’ Health Perceptions in Addressing Health Care Disparities.
Ethnicity & disease. 32(2):145-148 [DOI] 10.18865/ed.32.2.145. [PMID] 35497402.
2021
Adapting Clinical Practice of Thrombolysis for Acute Ischemic Stroke Beyond 4.5 Hours: A Review of the Literature.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 30(11) [DOI] 10.1016/j.jstrokecerebrovasdis.2021.106059. [PMID] 34464927.
2021
Benefits of an interdisciplinary stroke clinic: addressing a gap in physical therapy at post-stroke neurology follow-up
Disability and Rehabilitation. 1-6 [DOI] 10.1080/09638288.2021.2008527.
2021
Caveats to Acute Imaging for Acute Stroke in the Setting of Venoarterial Extracorporeal Membrane Oxygenation
Neurology: Clinical Practice. [DOI] 10.1212/cpj.0000000000001103.
2021
Cerebral Venous Thrombosis and Hypercoagulability Associated With In Vitro Fertilization
Stroke. 52(9) [DOI] 10.1161/strokeaha.121.035962.
2021
CT perfusion core and ASPECT score prediction of outcomes in DEFUSE 3.
International journal of stroke : official journal of the International Stroke Society. 16(3):288-294 [DOI] 10.1177/1747493020915141. [PMID] 32233746.
2021
Electric Fence Artifact on Ambulatory EEG and Review of Common EEG Electrical Artifacts
The Neurodiagnostic Journal. 61(3):150-156 [DOI] 10.1080/21646821.2021.1959217.
2021
Erratum to “Impact of COVID-19 on Future Ischemic Stroke Incidence” [eNeurologicalSci, 22C (2021) 100325].
eNeurologicalSci. 23 [DOI] 10.1016/j.ensci.2021.100342. [PMID] 33937535.
2021
Failure of Anticoagulation to Prevent Stroke in Context of Lupus-Associated Anti-Phospholipid Syndrome and Mild COVID-19
Journal of Stroke and Cerebrovascular Diseases. [DOI] 10.1016/j.jstrokecerebrovasdis.2021.105817. [PMID] 33933349.
2021
Giant Vertebrobasilar Fusiform Aneurysm Mass Effect Heralds Rapid in Situ Thrombosis and Ischemic Stroke in the Setting of Ulcerative Colitis
Journal of Stroke and Cerebrovascular Diseases. 30(4) [DOI] 10.1016/j.jstrokecerebrovasdis.2021.105621.
2021
Impact of COVID-19 on Future Ischemic Stroke Incidence.
eNeurologicalSci. 22 [DOI] 10.1016/j.ensci.2021.100325. [PMID] 33553699.
2021
Post-COVID seizure: A new feature of “long-COVID”.
eNeurologicalSci. 23 [DOI] 10.1016/j.ensci.2021.100340. [PMID] 33898792.
2021
Tipping the Scales for Older Adults: Time to Consider Body Fat Assessment and Management for Optimal Atherosclerotic Cardiovascular Disease and Stroke Prevention?
Journal of the American Heart Association. 10(9) [DOI] 10.1161/jaha.121.021307.
2020
A biventricular takotsubo cardiomyopathy complication: large thrombus formation to stroke in 150 min.
BMJ case reports. 13(9) [DOI] 10.1136/bcr-2020-235957. [PMID] 32878833.
2020
Biomarker Application for Precision Medicine in Stroke.
Translational stroke research. 11(4):615-627 [DOI] 10.1007/s12975-019-00762-3. [PMID] 31848851.
2020
Iodinated Contrast Extravasation on Post-Revascularization Computed Tomography Mimics Magnetic Resonance Hyperintense Acute Reperfusion Marker: A Case Study
Journal of Stroke and Cerebrovascular Diseases. 29(12) [DOI] 10.1016/j.jstrokecerebrovasdis.2020.105294.
2020
Iodinated Contrast Extravasation on Post-Revascularization Computed Tomography Mimics Magnetic Resonance Hyperintense Acute Reperfusion Marker: A Case Study
Journal of Stroke & Cerebrovascular Diseases. [DOI] 10.1016/j.strokecerebrovasdis.2020.105294.
2020
Musical hallucinations with a right frontotemporal stroke.
Neurocase. 26(5):313-316 [DOI] 10.1080/13554794.2020.1820529. [PMID] 32930641.
2020
Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions.
Neurology. 95(3):124-133 [DOI] 10.1212/WNL.0000000000009713. [PMID] 32385186.
2020
Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care
Neurocritical Care. 33(3):636-645 [DOI] 10.1007/s12028-020-01085-0. [PMID] 32959201.
2019
Acute Cerebral Ischemia Temporally Associated with Marijuana Use.
Cureus. 11(7) [DOI] 10.7759/cureus.5239. [PMID] 31565637.
2019
Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.
Annals of clinical and translational neurology. 6(4):817-820 [DOI] 10.1002/acn3.757. [PMID] 31020007.
2019
Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy.
Cerebrovascular diseases (Basel, Switzerland). 47(3-4):135-142 [DOI] 10.1159/000499666. [PMID] 30970357.
2019
The Efficacy of IV Tissue Plasminogen Activator for Restoring Cerebral Blood Flow in the Hours Immediately after Administration in Patients with Acute Stroke.
Journal of neuroimaging : official journal of the American Society of Neuroimaging. 29(2):206-210 [DOI] 10.1111/jon.12587. [PMID] 30508260.
2018
Blood-ocular barrier disruption in patients with acute stroke.
Neurology. 90(11):e915-e923 [DOI] 10.1212/WNL.0000000000005123. [PMID] 29438039.
2018
Recurrent thrombolysis of a stuttering lacunar infarction captured on serial MRIs.
eNeurologicalSci. 13:14-17 [DOI] 10.1016/j.ensci.2018.10.001. [PMID] 30450428.
2018
White Matter Hyperintensity-Associated Blood-Brain Barrier Disruption and Vascular Risk Factors.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 27(2):466-471 [DOI] 10.1016/j.jstrokecerebrovasdis.2017.09.026. [PMID] 29100854.
2017
Early Change in Stroke Size Performs Best in Predicting Response to Therapy.
Cerebrovascular diseases (Basel, Switzerland). 44(3-4):141-149 [DOI] 10.1159/000477945. [PMID] 28683442.
2016
Identification of Reversible Disruption of the Human Blood-Brain Barrier Following Acute Ischemia.
Stroke. 47(9):2405-8 [DOI] 10.1161/STROKEAHA.116.013805. [PMID] 27462115.
2016
Stuttering lacunar infarction captured on serial MRIs.
Neurology. Clinical practice. 6(5):e37-e39 [PMID] 27847687.
2013
Brachial plexitis preceding encephalomyelitis in a patient with West Nile virus infection.
BMJ case reports. 2013 [DOI] 10.1136/bcr-2013-200833. [PMID] 24311412.
2012
Complete resolution of advanced Mycoplasma pneumoniae encephalitis mimicking brain mass lesions: report of two pediatric cases and review of literature.
Neuropathology : official journal of the Japanese Society of Neuropathology. 32(1):91-9 [DOI] 10.1111/j.1440-1789.2011.01225.x. [PMID] 21615517.
2011
Cytochrome P450 eicosanoids and cerebral vascular function.
Expert reviews in molecular medicine. 13 [DOI] 10.1017/S1462399411001773. [PMID] 21356152.
2010
Soluble epoxide hydrolase inhibition modulates vascular remodeling.
American journal of physiology. Heart and circulatory physiology. 298(3):H795-806 [DOI] 10.1152/ajpheart.00543.2009. [PMID] 20035028.
2009
Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.
The American journal of pathology. 174(6):2086-95 [DOI] 10.2353/ajpath.2009.080544. [PMID] 19435785.
2004
Single slice method for quantification of hemorrhagic transformation using direct ELISA.
Neurological research. 26(1):93-8 [PMID] 14977065.

Education

Master's of Clinical Research
2017-2019 · Medical College of South Carolina
Clinical Research Fellowship – Vascular Neurology
2015-2017 · National Institute of Health
Clinical Fellowship – Vascular Neurology
2014-2015 · National Institute of Health
Residency – Neurology
2011-2014 · Johns Hopkins University
Internship – Internal Medicine
2010-2011 · Medical College of Georgia
Dual M.D./Ph.D. – Vascular Biology
2010 · Medical College of Georgia

Contact Details

Phones:
Business:
(352) 273-5550
Addresses:
Business Mailing:
PO BOX 103715
GAINESVILLE FL 326100001
Business Street:
1329 SW 16TH ST RM 1160
GAINESVILLE FL 32608