Alexis N Simpkins

Alexis N Simpkins, MD, PhD, MSCR, FAHA

Clinical Assistant Professor

Business Phone: (352) 273-5550

About Alexis N Simpkins

Alexis Nétis Simpkins, MD, PhD, MSCR, FAHA is an Assistant Professor of neurology in the University of Florida College of Medicine. Dr. Simpkins first earned a bachelor of science degree in chemistry, along with a minor in biology, at Augusta University in Georgia. She was then accepted into the dual doctoral program at the Medical College of Georgia in Augusta, obtaining her medical doctoral degree and a doctorate in vascular biology after investigating utility of a novel agent in vascular and neuroprotection in hypertension and stroke.

She completed her internal medicine internship at the Medical College of Georgia in Augusta. Next, she completed a neurology residency at The Johns Hopkins Hospital in Baltimore. Dr. Simpkins completed her time in Maryland with a combined clinical and research vascular neurology fellowship at the National Institute of Neurological Disorders and Stroke.

Dr. Simpkins is an active member in the American Heart Association and Director of the CREST Initiative for stroke trainee and fellow research and career development in the Vascular Neurology Division.


HEADSUP Junior Investigator Travel Award
2020 · American Heart Association, International Stroke Conference
Best Poster Award at the International Genetics Consortium
2019 · International Stroke Genetics Consortium
Recognized at top 10% abstract from International Stroke Conference for abstract “Secondary Stroke Prevention with Aspirin and Clopidogrel in CYP2C19*17 Carriers Increases Risk of Major Non-CNS Bleeding” of 2019
2019 · American Heart Association
2017 · American Academy of Neurology
First prize winner of the Stroke Progress and Innovation Award
2016 · Stroke (medical journal)
VA Chief of Neurology Award
2009 · Medical College of Georgia

Board Certifications

  • ABPN Neurology Boards
  • ABPN Vascular Neurology Boards
    Vascular Neurology

Clinical Profile

  • Neurology
Areas of Interest
  • Acute Ischemic Stroke
  • Stroke

Research Profile

Areas of Interest
  • Advanced MRI and stroke
  • Blood biomarkers and stroke
  • Monitoring and evaluating stroke therapy
  • Protective and preventive measures of cerebrovascular disorders (cerebral ischemia, vascular remodeling and neurological imaging)
  • Stroke recovery


CT perfusion core and ASPECT score prediction of outcomes in DEFUSE 3.
International journal of stroke : official journal of the International Stroke Society. 16(3):288-294 [DOI] 10.1177/1747493020915141. [PMID] 32233746.
Giant Vertebrobasilar Fusiform Aneurysm Mass Effect Heralds Rapid in Situ Thrombosis and Ischemic Stroke in the Setting of Ulcerative Colitis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 30(4) [DOI] 10.1016/j.jstrokecerebrovasdis.2021.105621. [PMID] 33581546.
Impact of COVID-19 on Future Ischemic Stroke Incidence.
eNeurologicalSci. 22 [DOI] 10.1016/j.ensci.2021.100325. [PMID] 33553699.
Post-COVID seizure: A new feature of “long-COVID”.
eNeurologicalSci. 23 [DOI] 10.1016/j.ensci.2021.100340. [PMID] 33898792.
Tipping the Scales for Older Adults: Time to Consider Body Fat Assessment and Management for Optimal Atherosclerotic Cardiovascular Disease and Stroke Prevention?
Journal of the American Heart Association. 10(9) [DOI] 10.1161/JAHA.121.021307. [PMID] 33870706.
A biventricular takotsubo cardiomyopathy complication: large thrombus formation to stroke in 150 min.
BMJ case reports. 13(9) [DOI] 10.1136/bcr-2020-235957. [PMID] 32878833.
Biomarker Application for Precision Medicine in Stroke.
Translational stroke research. 11(4):615-627 [DOI] 10.1007/s12975-019-00762-3. [PMID] 31848851.
Iodinated Contrast Extravasation on Post-Revascularization Computed Tomography Mimics Magnetic Resonance Hyperintense Acute Reperfusion Marker: A Case Study
Journal of Stroke & Cerebrovascular Diseases. [DOI] 10.1016/j.strokecerebrovasdis.2020.105294.
Iodinated Contrast Extravasation on Post-Revascularization Computed Tomography Mimics Magnetic Resonance Hyperintense Acute Reperfusion Marker: A Case Study.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 29(12) [DOI] 10.1016/j.jstrokecerebrovasdis.2020.105294. [PMID] 32992195.
Musical hallucinations with a right frontotemporal stroke.
Neurocase. 26(5):313-316 [DOI] 10.1080/13554794.2020.1820529. [PMID] 32930641.
Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions.
Neurology. 95(3):124-133 [DOI] 10.1212/WNL.0000000000009713. [PMID] 32385186.
Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care.
Neurocritical care. [DOI] 10.1007/s12028-020-01085-0. [PMID] 32959201.
Acute Cerebral Ischemia Temporally Associated with Marijuana Use.
Cureus. 11(7) [DOI] 10.7759/cureus.5239. [PMID] 31565637.
Early Change in Stroke Size Performs Best in Predicting Response to Therapy.
Cerebrovascular diseases (Basel, Switzerland). 44(3-4):141-149 [DOI] 10.1159/000477945. [PMID] 28683442.
Identification of Reversible Disruption of the Human Blood-Brain Barrier Following Acute Ischemia.
Stroke. 47(9):2405-8 [DOI] 10.1161/STROKEAHA.116.013805. [PMID] 27462115.
Stuttering lacunar infarction captured on serial MRIs.
Neurology. Clinical practice. 6(5):e37-e39 [PMID] 27847687.
View on: PubMed
Brachial plexitis preceding encephalomyelitis in a patient with West Nile virus infection.
BMJ case reports. 2013 [DOI] 10.1136/bcr-2013-200833. [PMID] 24311412.
Complete resolution of advanced Mycoplasma pneumoniae encephalitis mimicking brain mass lesions: report of two pediatric cases and review of literature.
Neuropathology : official journal of the Japanese Society of Neuropathology. 32(1):91-9 [DOI] 10.1111/j.1440-1789.2011.01225.x. [PMID] 21615517.
Cytochrome P450 eicosanoids and cerebral vascular function.
Expert reviews in molecular medicine. 13 [DOI] 10.1017/S1462399411001773. [PMID] 21356152.
Soluble epoxide hydrolase inhibition modulates vascular remodeling.
American journal of physiology. Heart and circulatory physiology. 298(3):H795-806 [DOI] 10.1152/ajpheart.00543.2009. [PMID] 20035028.
Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.
The American journal of pathology. 174(6):2086-95 [DOI] 10.2353/ajpath.2009.080544. [PMID] 19435785.
Single slice method for quantification of hemorrhagic transformation using direct ELISA.
Neurological research. 26(1):93-8 [PMID] 14977065.
View on: PubMed


Master's of Clinical Research
2017-2019 · Medical College of South Carolina
Clinical Research Fellowship – Vascular Neurology
2015-2017 · National Institute of Health
Clinical Fellowship – Vascular Neurology
2014-2015 · National Institute of Health
Residency – Neurology
2011-2014 · Johns Hopkins University
Internship – Internal Medicine
2010-2011 · Medical College of Georgia
Dual M.D./Ph.D. – Vascular Biology
2010 · Medical College of Georgia

Teaching Profile

Courses Taught
PHA6613 Clinical Applications Precision Medicine: Precision Health

Contact Details

(352) 273-5550