Vinata Vedam-Mai

Vinata Vedam-Mai, PhD

Research Assistant Professor

Department: MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone: (352) 273-8583
Business Email: vinved@neurology.ufl.edu

About Vinata Vedam-Mai

Dr. Vedam-Mai is an Assistant Professor at the Dept. of Neurology and the Fixel Institute at the University of Florida. She received her PhD from the University of Georgia, and received her BS and MS degrees from Bangalore University in India. Research in her lab focuses on comprehending mechanisms of neuronal demise in neurodegenerative diseases in order to improve therapeutic strategies for their treatment. Specifically, there are three main thrust areas to her work: 1) Studying the effect of chronic electrical stimulation [such as Deep Brain Stimulation, DBS] on the neurogenic niches of the brain, and comprehending the cellular-molecular processes affected via this surgical procedure. 2) To develop a novel immunomodulatory platform for the treatment of PD and to identify the role of the peripheral immune system in the efficacy of this therapeutic platform [in a preclinical model]. 3) Understanding the brain “metabolome” in aging and disease.

Dr. Vedam-Mai has mentored several students in the laboratory setting belonging to diverse backgrounds. She currently serves as a mentor for the University Multicultural Mentor Program (UMMP). She is also a board member for the Academic Association for Women (AAW) at UF. She is a member of the Women in Medicine and Science (WIMS) group at UF. She is trained in Indian classical dance and music and performs routinely at various cultural events. She also enjoys playing tennis, traveling, cooking, reading, and spending time with her family.

Research Profile

Areas of Interest
  • Deep brain stimulation
  • Gut Microbiome
  • Parkinson’s disease
Open Researcher and Contributor ID (ORCID)

0000-0003-0148-3297

Publications

2022
Advancing Our Understanding of Brain Disorders: Research Using Postmortem Brain Tissue.
Methods in molecular biology (Clifton, N.J.). 2389:201-208 [DOI] 10.1007/978-1-0716-1783-0_16. [PMID] 34558012.
2022
Biovalue in Human Brain Banking: Applications and Challenges for Research in Neurodegenerative Diseases.
Methods in molecular biology (Clifton, N.J.). 2389:209-220 [DOI] 10.1007/978-1-0716-1783-0_17. [PMID] 34558013.
2021
Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience. 15 [DOI] 10.3389/fnhum.2021.765150. [PMID] 34658825.
2021
Harnessing the immune system for the treatment of Parkinson’s disease.
Brain research. 1758 [DOI] 10.1016/j.brainres.2021.147308. [PMID] 33524380.
2021
Mass Spectrometry-Based Cellular Metabolomics: Current Approaches, Applications, and Future Directions.
Analytical chemistry. 93(1):546-566 [DOI] 10.1021/acs.analchem.0c04363. [PMID] 33146525.
2021
Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience. 15 [DOI] 10.3389/fnhum.2021.644593. [PMID] 33953663.
2021
The Gut-Brain Axis and Its Relation to Parkinson’s Disease: A Review.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.782082. [PMID] 35069178.
2020
Design and Implementation of a Dual-Probe Microsampling Apparatus for the Direct Analysis of Adherent Mammalian Cells by Ion Mobility-Mass Spectrometry.
Analytical chemistry. 92(17):12055-12061 [DOI] 10.1021/acs.analchem.0c02714. [PMID] 32786468.
2020
Gut Microbiota Dynamics in Parkinsonian Mice
ACS Chemical Neuroscience. 11(20):3267-3276 [DOI] 10.1021/acschemneuro.0c00386.
2020
Ultrahigh-Performance Liquid Chromatography–High-Resolution Mass Spectrometry Metabolomics and Lipidomics Study of Stool from Transgenic Parkinson’s Disease Mice Following Immunotherapy
Journal of Proteome Research. 19(1):424-431 [DOI] 10.1021/acs.jproteome.9b00605.
2020
α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(34):6649-6659 [DOI] 10.1523/JNEUROSCI.0189-20.2020. [PMID] 32669353.
2019
Emerging therapies in Parkinson disease – repurposed drugs and new approaches.
Nature reviews. Neurology. 15(4):204-223 [DOI] 10.1038/s41582-019-0155-7. [PMID] 30867588.
2019
Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics.
Frontiers in neuroscience. 13 [DOI] 10.3389/fnins.2019.00936. [PMID] 31572109.
2018
l-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells
ACS Chemical Neuroscience. 9(5):901-905 [DOI] 10.1021/acschemneuro.7b00468.
2018
Deep Brain Stimulation associated gliosis: A post-mortem study.
Parkinsonism & related disorders. 54:51-55 [DOI] 10.1016/j.parkreldis.2018.04.009. [PMID] 29653910.
2018
Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s Disease: Current Progress and Future Perspectives.
Analytical chemistry. 90(5):2979-2986 [DOI] 10.1021/acs.analchem.7b04084. [PMID] 29384654.
2017
Monitoring Dopamine ex Vivo during Electrical Stimulation Using Liquid-Microjunction Surface Sampling.
Analytical chemistry. 89(24):13658-13665 [DOI] 10.1021/acs.analchem.7b04463. [PMID] 29088914.
2017
Precast Gelatin-Based Molds for Tissue Embedding Compatible with Mass Spectrometry Imaging.
Analytical chemistry. 89(1):576-580 [DOI] 10.1021/acs.analchem.6b04185. [PMID] 27935272.
2016
A Supplemented High-Fat Low-Carbohydrate Diet for the Treatment of Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(10):2482-95 [DOI] 10.1158/1078-0432.CCR-15-0916. [PMID] 26631612.
2016
Post-mortem Findings in Huntington’s Deep Brain Stimulation: A Moving Target Due to Atrophy.
Tremor and other hyperkinetic movements (New York, N.Y.). 6 [DOI] 10.7916/D8ZP462H. [PMID] 27127722.
2016
Tissue Response to Deep Brain Stimulation and Microlesion: A Comparative Study.
Neuromodulation : journal of the International Neuromodulation Society. 19(5):451-8 [DOI] 10.1111/ner.12406. [PMID] 27018335.
2016
Transplantation of Defined Populations of Differentiated Human Neural Stem Cell Progeny.
Scientific reports. 6 [DOI] 10.1038/srep23579. [PMID] 27030542.
2015
Differential connexin function enhances self-renewal in glioblastoma.
Cell reports. 11(7):1031-42 [DOI] 10.1016/j.celrep.2015.04.021. [PMID] 25959821.
2014
Increased precursor cell proliferation after deep brain stimulation for Parkinson’s disease: a human study.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0088770. [PMID] 24594681.
2014
The “brittle response” to Parkinson’s disease medications: characterization and response to deep brain stimulation.
PloS one. 9(4) [DOI] 10.1371/journal.pone.0094856. [PMID] 24733172.
2013
Gap Junction Switching Maintains the Tumor Hierarchy in Glioblastoma
Neuro-Oncology. 15(3):210-211
2012
Deep brain stimulation and the role of astrocytes.
Molecular psychiatry. 17(2):124-31, 115 [DOI] 10.1038/mp.2011.61. [PMID] 21625231.
2012
Deep brain stimulation response in pathologically confirmed cases of multiple system atrophy.
Parkinsonism & related disorders. 18(1):86-8 [DOI] 10.1016/j.parkreldis.2011.09.008. [PMID] 21983018.
2012
Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.
Brain research. 1464:61-72 [DOI] 10.1016/j.brainres.2012.04.039. [PMID] 22652067.
2012
Postmortem observation of collagenous lead tip region fibrosis as a rare complication of DBS.
Movement disorders : official journal of the Movement Disorder Society. 27(4):565-9 [DOI] 10.1002/mds.24916. [PMID] 22314706.
2011
A pilot study of human brain tissue post-magnetic resonance imaging: information from the National Deep Brain Stimulation Brain Tissue Network (DBS-BTN).
NeuroImage. 54 Suppl 1:S233-7 [DOI] 10.1016/j.neuroimage.2010.09.014. [PMID] 20849960.
2011
Collagenous Fibrosis: a Rare Tissue Reaction of Deep Brain Stimulation (Dbs)
Journal of Neuropathology and Experimental Neurology. 70
2011
Isolation and characterization of adult neural stem cells.
Methods in molecular biology (Clifton, N.J.). 750:61-77 [DOI] 10.1007/978-1-61779-145-1_4. [PMID] 21618083.
2011
Neural-colony forming cell assay: an assay to discriminate bona fide neural stem cells from neural progenitor cells.
Journal of visualized experiments : JoVE. (49) [DOI] 10.3791/2639. [PMID] 21403640.
2011
The cancer stem cell hypothesis: failures and pitfalls.
Neurosurgery. 68(2):531-45; discussion 545 [DOI] 10.1227/NEU.0b013e3181ff9eb5. [PMID] 21135745.
2011
The national DBS brain tissue network pilot study: need for more tissue and more standardization.
Cell and tissue banking. 12(3):219-31 [DOI] 10.1007/s10561-010-9189-1. [PMID] 20589432.
2010
Disrupting abnormal electrical activity with deep brain stimulation: is epilepsy the next frontier?
Neurosurgical focus. 29(2) [DOI] 10.3171/2010.4.FOCUS10104. [PMID] 20672924.

Grants

Jun 2020 ACTIVE
Dentatothalamocortical circuit and its neumodulation in Spinocerebellar ataxias
Role: Principal Investigator
Funding: ALBANY MEDICAL COLLEGE via NATL INST OF HLTH NINDS
Apr 2020 ACTIVE
CTOA
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Sep 2019 – Aug 2022
Adoptive Cell Therapies and Translational Neuroimaging in Synucleinopathy: Implications for Dementia with Lewy Body and Parkinson's Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Mar 2019 – Mar 2022
Ataxia Research Fund: Support for Ataxia research and education
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2018 – Jun 2022
A Novel Vaccine Based Approach for the Treatment of Lewy Body Diseases
Role: Principal Investigator
Funding: UF FOUNDATION via HARRY T MANGURIAN JR FOU
Jun 2016 – May 2022
DEVELOPMENT OF A VACCINE BASED THERAPY FOR PARKINSONS DISEASE
Role: Principal Investigator
Funding: *UF FOU SHARE

Education

PhD
2004 · University of Georgia, Athens
MS
1997 · Bangalore University
BS
1995 · Mount Carmel College, Bangalore

Contact Details

Phones:
Business:
(352) 273-8583
Emails:
Addresses:
Business Mailing:
L3-100, MBI
1149 NEWELL DR
PO BOX 100236
GAINESVILLE FL 32611
Business Street:
MCKNIGHT BRAIN INSTITUTE, L3-171
UNIVERSITY OF FL
1149, SOUTH NEWELL DRIVE,
GAINESVILLE FL 326110001