Hong Xing

Hong Xing,

Assistant In

Department: MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone: (352) 392-0670
Business Email: hongxing@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9909-2333

Publications

2023
Motor deficit and lack of overt dystonia in Dlx conditional Dyt1 knockout mice.
Behavioural brain research. 439 [DOI] 10.1016/j.bbr.2022.114221. [PMID] 36417958.
2022
Electrophysiological characterization of the striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice.
Dystonia. 1 [DOI] 10.3389/dyst.2022.10557. [PMID] 36329866.
2022
Further Studies on the Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.
Neuroscience. 505:78-90 [DOI] 10.1016/j.neuroscience.2022.10.008. [PMID] 36244636.
2022
Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice.
Molecular and cellular neurosciences. 121 [DOI] 10.1016/j.mcn.2022.103756. [PMID] 35843530.
2022
Interactions of Nereistoxin and Its Analogs with Vertebrate Nicotinic Acetylcholine Receptors and Molluscan ACh Binding Proteins.
Marine drugs. 20(1) [DOI] 10.3390/md20010049. [PMID] 35049904.
2021
Alteration of the cholinergic system and motor deficits in cholinergic neuron-specific Dyt1 knockout mice.
Neurobiology of disease. 154 [DOI] 10.1016/j.nbd.2021.105342. [PMID] 33757902.
2021
Characterization of the direct pathway in Dyt1 ΔGAG heterozygous knock-in mice and dopamine receptor 1-expressing-cell-specific Dyt1 conditional knockout mice.
Behavioural brain research. 411 [DOI] 10.1016/j.bbr.2021.113381. [PMID] 34038798.
2021
Investigating the role of striatal dopamine receptor 2 in motor coordination and balance: Insights into the pathogenesis of DYT1 dystonia.
Behavioural brain research. 403 [DOI] 10.1016/j.bbr.2021.113137. [PMID] 33476687.
2020
A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in Its Interactions with α7 and α4β2 Nicotinic Acetylcholine Receptors.
Molecular pharmacology. 98(2):168-180 [DOI] 10.1124/mol.119.118786. [PMID] 32474444.
2020
A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine.
Marine drugs. 18(2) [DOI] 10.3390/md18020106. [PMID] 32053997.
2020
BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome.
Brain structure & function. 225(6):1743-1760 [DOI] 10.1007/s00429-020-02090-x. [PMID] 32468214.
2020
Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice.
Neurobiology of disease. 134 [DOI] 10.1016/j.nbd.2019.104638. [PMID] 31618684.
2020
Deficiency of Meis1, a transcriptional regulator, in mice and worms: Neurochemical and behavioral characterizations with implications in the restless legs syndrome.
Journal of neurochemistry. 155(5):522-537 [DOI] 10.1111/jnc.15177. [PMID] 32910473.
2020
The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia.
Brain research bulletin. 165:14-22 [DOI] 10.1016/j.brainresbull.2020.09.011. [PMID] 32976982.
2020
The Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.
Neuroscience. 440:85-96 [DOI] 10.1016/j.neuroscience.2020.05.021. [PMID] 32446853.
2020
The role of BTBD9 in the cerebral cortex and the pathogenesis of restless legs syndrome.
Experimental neurology. 323 [DOI] 10.1016/j.expneurol.2019.113111. [PMID] 31715135.
2019
Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine.
Marine drugs. 17(11) [DOI] 10.3390/md17110614. [PMID] 31671780.
2019
The Role of BTBD9 in Striatum and Restless Legs Syndrome.
eNeuro. 6(5) [DOI] 10.1523/ENEURO.0277-19.2019. [PMID] 31444227.
2017
Comparison of tumor biology of two distinct cell sub-populations in lung cancer stem cells.
Oncotarget. 8(57):96852-96864 [DOI] 10.18632/oncotarget.18451. [PMID] 29228576.
2015
Non-competitive Inhibition of Nicotinic Acetylcholine Receptors by Ladybird Beetle Alkaloids.
Neurochemical research. 40(10):2078-86 [DOI] 10.1007/s11064-014-1466-0. [PMID] 25370792.
2013
APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma.
Marine drugs. 11(7):2574-94 [DOI] 10.3390/md11072574. [PMID] 23880932.
2009
Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity.
Neuromolecular medicine. 11(2):63-75 [DOI] 10.1007/s12017-009-8073-2. [PMID] 19562525.
2009
Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors.
British journal of pharmacology. 157(2):320-30 [DOI] 10.1111/j.1476-5381.2009.00156.x. [PMID] 19338581.
2009
Lsoanatabine, a Naturally Occurring Alpha 4 Beta 2 Nicotinic Receptor Agonist
Biochemical Pharmacology. 78(7):906-907 [DOI] 10.1016/j.bcp.2009.06.047.
2008
TRPM8 mechanism of autonomic nerve response to cold in respiratory airway.
Molecular pain. 4 [DOI] 10.1186/1744-8069-4-22. [PMID] 18534015.
2007
TRPM8 mechanism of cold allodynia after chronic nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(50):13680-90 [PMID] 18077679.
2006
Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons.
Journal of neurophysiology. 95(2):1221-30 [PMID] 16424459.
2005
Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord.
Molecular pain. 1 [PMID] 15987503.
2004
Menthol-induced Ca2+ release from presynaptic Ca2+ stores potentiates sensory synaptic transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(3):762-71 [PMID] 14736862.

Grants

Sep 2022 ACTIVE
Pathophysiology of DYT1 dystonia: Targeted Mouse Models
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Mar 2021 – Mar 2024
Novel Therapy Development for Dystonia
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2020 – Aug 2023
Characterization of Meis1 mutant mice and implications in restless legs syndrome and other sleep disorders
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2020 – Jul 2023
Characterization of the involvement of the cerebellum in animal models of C9orf72 ALS/FTD
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2018 – Dec 2021
Chemogenetic modulation of striatal cholinergic interneurons in DYT1 dystonia
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION

Contact Details

Phones:
Business:
(352) 392-0670
Emails:
Business:
hongxing@ufl.edu
Addresses:
Business Mailing:
PO Box 100236
GAINESVILLE FL 32610