Fumiaki Yokoi

Fumiaki Yokoi,

Assistant Professor

Department: MD-NEUROLOGY-ADMIN/EDUC
Business Phone: (352) 273-6631
Business Email: fyokoi@ufl.edu

Publications

2022
Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice.
Molecular and cellular neurosciences. 121 [DOI] 10.1016/j.mcn.2022.103756. [PMID] 35843530.
2021
Alteration of the cholinergic system and motor deficits in cholinergic neuron-specific Dyt1 knockout mice.
Neurobiology of disease. 154 [DOI] 10.1016/j.nbd.2021.105342. [PMID] 33757902.
2021
Characterization of the direct pathway in Dyt1 ΔGAG heterozygous knock-in mice and dopamine receptor 1-expressing-cell-specific Dyt1 conditional knockout mice.
Behavioural brain research. 411 [DOI] 10.1016/j.bbr.2021.113381. [PMID] 34038798.
2021
Investigating the role of striatal dopamine receptor 2 in motor coordination and balance: Insights into the pathogenesis of DYT1 dystonia.
Behavioural brain research. 403 [DOI] 10.1016/j.bbr.2021.113137. [PMID] 33476687.
2021
Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice.
IBRO neuroscience reports. 11:1-7 [DOI] 10.1016/j.ibneur.2021.05.003. [PMID] 34189496.
2020
BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome.
Brain structure & function. 225(6):1743-1760 [DOI] 10.1007/s00429-020-02090-x. [PMID] 32468214.
2020
Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice.
Neurobiology of disease. 134 [DOI] 10.1016/j.nbd.2019.104638. [PMID] 31618684.
2020
Deficiency of Meis1, a transcriptional regulator, in mice and worms: Neurochemical and behavioral characterizations with implications in the restless legs syndrome.
Journal of neurochemistry. 155(5):522-537 [DOI] 10.1111/jnc.15177. [PMID] 32910473.
2020
Improved survival and overt “dystonic” symptoms in a torsinA hypofunction mouse model.
Behavioural brain research. 381 [DOI] 10.1016/j.bbr.2019.112451. [PMID] 31891745.
2020
The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia.
Brain research bulletin. 165:14-22 [DOI] 10.1016/j.brainresbull.2020.09.011. [PMID] 32976982.
2020
The Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.
Neuroscience. 440:85-96 [DOI] 10.1016/j.neuroscience.2020.05.021. [PMID] 32446853.
2020
The role of BTBD9 in the cerebral cortex and the pathogenesis of restless legs syndrome.
Experimental neurology. 323 [DOI] 10.1016/j.expneurol.2019.113111. [PMID] 31715135.
2019
The Role of BTBD9 in Striatum and Restless Legs Syndrome.
eNeuro. 6(5) [DOI] 10.1523/ENEURO.0277-19.2019. [PMID] 31444227.
2016
Electromyographic evidence in support of a knock-in mouse model of DYT1 Dystonia.
Movement disorders : official journal of the Movement Disorder Society. 31(11):1633-1639 [DOI] 10.1002/mds.26677. [PMID] 27241685.
2015
Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice.
PloS one. 10(3) [DOI] 10.1371/journal.pone.0120916. [PMID] 25799505.
2015
Decreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice.
Behavioural brain research. 279:202-10 [DOI] 10.1016/j.bbr.2014.11.037. [PMID] 25451552.
2013
Engineering animal models of dystonia.
Movement disorders : official journal of the Movement Disorder Society. 28(7):990-1000 [DOI] 10.1002/mds.25583. [PMID] 23893455.
2013
Pre-synaptic release deficits in a DYT1 dystonia mouse model.
PloS one. 8(8) [DOI] 10.1371/journal.pone.0072491. [PMID] 23967309.
2012
Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models.
Behavioural brain research. 227(1):12-20 [DOI] 10.1016/j.bbr.2011.10.024. [PMID] 22040906.
2012
Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse models.
Human molecular genetics. 21(4):916-25 [DOI] 10.1093/hmg/ddr528. [PMID] 22080833.
2012
Alteration of striatal dopaminergic neurotransmission in a mouse model of DYT11 myoclonus-dystonia.
PloS one. 7(3) [DOI] 10.1371/journal.pone.0033669. [PMID] 22438980.
2012
An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.
Behavioural brain research. 226(2):465-72 [DOI] 10.1016/j.bbr.2011.10.002. [PMID] 21995941.
2012
Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA.
Neurobiology of disease. 47(3):416-27 [DOI] 10.1016/j.nbd.2012.04.015. [PMID] 22579992.
2012
Enhanced hippocampal long-term potentiation and fear memory in Btbd9 mutant mice.
PloS one. 7(4) [DOI] 10.1371/journal.pone.0035518. [PMID] 22536397.
2012
Improved motor performance in Dyt1 ΔGAG heterozygous knock-in mice by cerebellar Purkinje-cell specific Dyt1 conditional knocking-out.
Behavioural brain research. 230(2):389-98 [DOI] 10.1016/j.bbr.2012.02.029. [PMID] 22391119.
2011
Altered dendritic morphology of Purkinje cells in Dyt1 ΔGAG knock-in and purkinje cell-specific Dyt1 conditional knockout mice.
PloS one. 6(3) [DOI] 10.1371/journal.pone.0018357. [PMID] 21479250.
2011
Characterization of Atp1a3 mutant mice as a model of rapid-onset dystonia with parkinsonism.
Behavioural brain research. 216(2):659-65 [DOI] 10.1016/j.bbr.2010.09.009. [PMID] 20850480.
2011
Motor deficits and decreased striatal dopamine receptor 2 binding activity in the striatum-specific Dyt1 conditional knockout mice.
PloS one. 6(9) [DOI] 10.1371/journal.pone.0024539. [PMID] 21931745.
2010
Chemical enhancement of torsinA function in cell and animal models of torsion dystonia.
Disease models & mechanisms. 3(5-6):386-96 [DOI] 10.1242/dmm.003715. [PMID] 20223934.
2010
Earlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.
Journal of biochemistry. 148(4):459-66 [DOI] 10.1093/jb/mvq078. [PMID] 20627944.
2009
A mental retardation gene, motopsin/neurotrypsin/prss12, modulates hippocampal function and social interaction.
The European journal of neuroscience. 30(12):2368-78 [DOI] 10.1111/j.1460-9568.2009.07029.x. [PMID] 20092579.
2009
Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in Dyt1 DeltaGAG knock-in mice.
Neuroscience research. 65(3):228-35 [DOI] 10.1016/j.neures.2009.07.004. [PMID] 19619587.
2008
Motor deficits and hyperactivity in cerebral cortex-specific Dyt1 conditional knockout mice.
Journal of biochemistry. 143(1):39-47 [PMID] 17956903.
2006
Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.
Proceedings of the National Academy of Sciences of the United States of America. 103(41):15254-9 [PMID] 17015831.
2006
Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism.
Biochemical and biophysical research communications. 341(3):691-6 [PMID] 16430861.
2006
Motor deficits and hyperactivity in Dyt1 knockdown mice.
Neuroscience research. 56(4):470-4 [PMID] 17046090.
2006
Myoclonus, motor deficits, alterations in emotional responses and monoamine metabolism in epsilon-sarcoglycan deficient mice.
Journal of biochemistry. 140(1):141-6 [PMID] 16815860.
2005
Exclusive paternal expression and novel alternatively spliced variants of epsilon-sarcoglycan mRNA in mouse brain.
FEBS letters. 579(21):4822-8 [PMID] 16099459.
2005
Generation and characterization of Dyt1 DeltaGAG knock-in mouse as a model for early-onset dystonia.
Experimental neurology. 196(2):452-63 [PMID] 16242683.
2003
Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase.
Journal of biochemistry. 133(5):607-14 [PMID] 12801912.
2002
A new organotypic culture of thyroid tissue maintains three-dimensional follicles with C cells for a long term.
Biochemical and biophysical research communications. 294(4):906-11 [PMID] 12061793.
2000
Air exposure promotes fibroblast growth with increased expression of mitogen-activated protein kinase cascade.
Biochemical and biophysical research communications. 270(3):961-6 [PMID] 10772933.
2000
Radiolabeled neuronal nitric oxide synthase inhibitors: synthesis, in vivo evaluation, and primate PET studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 41(8):1417-25 [PMID] 10945536.
1999
Bovine liver phosphoamidase as a protein histidine/lysine phosphatase.
Journal of biochemistry. 126(2):368-74 [PMID] 10423531.
1999
Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.
Synapse (New York, N.Y.). 32(1):44-50 [PMID] 10188637.
1999
GBR12909 attenuates amphetamine-induced striatal dopamine release as measured by [(11)C]raclopride continuous infusion PET scans.
Synapse (New York, N.Y.). 33(4):268-73 [PMID] 10421707.
1998
3-phosphohistidine and 6-phospholysine are substrates of a 56-kDa inorganic pyrophosphatase from bovine liver.
Archives of biochemistry and biophysics. 349(2):381-7 [PMID] 9448729.
1998
Dopamine transporter changes in neuropsychiatric disorders.
Advances in pharmacology (San Diego, Calif.). 42:219-23 [PMID] 9327883.
1997
Purification and characterization of hepatic inorganic pyrophosphatase hydrolyzing imidodiphosphate.
Archives of biochemistry and biophysics. 341(1):153-9 [PMID] 9143364.
1996
N(omega)-phosphoarginine phosphatase (17 kDa) and alkaline phosphatase as protein arginine phosphatases.
Journal of biochemistry. 119(4):719-24 [PMID] 8743574.
1993
The existence of pre-mature 16S rRNA species in plastid ribosomes.
FEBS letters. 327(1):29-31 [PMID] 8335092.
1992
Dopamine transporter imaging with novel, selective cocaine analogs.
Neuroreport. 3(11):969-72 [PMID] 1482766.
1992
Tobacco chloroplast ribosomes contain a homologue of E. coli ribosomal protein L28.
FEBS letters. 308(3):258-60 [PMID] 1505663.
1991
The chloroplast gene for ribosomal protein CL23 is functional in tobacco.
FEBS letters. 281(1-2):64-6 [PMID] 1707833.
1990
Chloroplast ribosomal protein L32 is encoded in the chloroplast genome.
FEBS letters. 276(1-2):88-90 [PMID] 2265719.
1988
Nucleotide sequence of the gene coding for cytochrome oxidase subunit I from the thermophilic bacterium PS3.
Journal of biochemistry. 103(4):606-10 [PMID] 2844737.

Grants

Jun 2018 – Dec 2021
Chemogenetic modulation of striatal cholinergic interneurons in DYT1 dystonia
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION

Contact Details

Phones:
Business:
(352) 273-6631
Emails:
Business:
fyokoi@ufl.edu
Addresses:
Business Mailing:
PO Box 100236
GAINESVILLE FL 32610
Business Street:
PO Box 100236
GAINESVILLE FL 32610