Fumiaki Yokoi,
Assistant Professor
Publications
2022
Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice.
Molecular and cellular neurosciences.
121
[DOI] 10.1016/j.mcn.2022.103756.
[PMID] 35843530.
2021
Alteration of the cholinergic system and motor deficits in cholinergic neuron-specific Dyt1 knockout mice.
Neurobiology of disease.
154
[DOI] 10.1016/j.nbd.2021.105342.
[PMID] 33757902.
2021
Characterization of the direct pathway in Dyt1 ΔGAG heterozygous knock-in mice and dopamine receptor 1-expressing-cell-specific Dyt1 conditional knockout mice.
Behavioural brain research.
411
[DOI] 10.1016/j.bbr.2021.113381.
[PMID] 34038798.
2021
Investigating the role of striatal dopamine receptor 2 in motor coordination and balance: Insights into the pathogenesis of DYT1 dystonia.
Behavioural brain research.
403
[DOI] 10.1016/j.bbr.2021.113137.
[PMID] 33476687.
2021
Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice.
IBRO neuroscience reports.
11:1-7
[DOI] 10.1016/j.ibneur.2021.05.003.
[PMID] 34189496.
2020
BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome.
Brain structure & function.
225(6):1743-1760
[DOI] 10.1007/s00429-020-02090-x.
[PMID] 32468214.
2020
Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice.
Neurobiology of disease.
134
[DOI] 10.1016/j.nbd.2019.104638.
[PMID] 31618684.
2020
Deficiency of Meis1, a transcriptional regulator, in mice and worms: Neurochemical and behavioral characterizations with implications in the restless legs syndrome.
Journal of neurochemistry.
155(5):522-537
[DOI] 10.1111/jnc.15177.
[PMID] 32910473.
2020
Improved survival and overt “dystonic” symptoms in a torsinA hypofunction mouse model.
Behavioural brain research.
381
[DOI] 10.1016/j.bbr.2019.112451.
[PMID] 31891745.
2020
The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia.
Brain research bulletin.
165:14-22
[DOI] 10.1016/j.brainresbull.2020.09.011.
[PMID] 32976982.
2020
The Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.
Neuroscience.
440:85-96
[DOI] 10.1016/j.neuroscience.2020.05.021.
[PMID] 32446853.
2020
The role of BTBD9 in the cerebral cortex and the pathogenesis of restless legs syndrome.
Experimental neurology.
323
[DOI] 10.1016/j.expneurol.2019.113111.
[PMID] 31715135.
2019
The Role of BTBD9 in Striatum and Restless Legs Syndrome.
eNeuro.
6(5)
[DOI] 10.1523/ENEURO.0277-19.2019.
[PMID] 31444227.
2016
Electromyographic evidence in support of a knock-in mouse model of DYT1 Dystonia.
Movement disorders : official journal of the Movement Disorder Society.
31(11):1633-1639
[DOI] 10.1002/mds.26677.
[PMID] 27241685.
2015
Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice.
PloS one.
10(3)
[DOI] 10.1371/journal.pone.0120916.
[PMID] 25799505.
2015
Decreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice.
Behavioural brain research.
279:202-10
[DOI] 10.1016/j.bbr.2014.11.037.
[PMID] 25451552.
2013
Engineering animal models of dystonia.
Movement disorders : official journal of the Movement Disorder Society.
28(7):990-1000
[DOI] 10.1002/mds.25583.
[PMID] 23893455.
2013
Pre-synaptic release deficits in a DYT1 dystonia mouse model.
PloS one.
8(8)
[DOI] 10.1371/journal.pone.0072491.
[PMID] 23967309.
2012
Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models.
Behavioural brain research.
227(1):12-20
[DOI] 10.1016/j.bbr.2011.10.024.
[PMID] 22040906.
2012
Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse models.
Human molecular genetics.
21(4):916-25
[DOI] 10.1093/hmg/ddr528.
[PMID] 22080833.
2012
Alteration of striatal dopaminergic neurotransmission in a mouse model of DYT11 myoclonus-dystonia.
PloS one.
7(3)
[DOI] 10.1371/journal.pone.0033669.
[PMID] 22438980.
2012
An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.
Behavioural brain research.
226(2):465-72
[DOI] 10.1016/j.bbr.2011.10.002.
[PMID] 21995941.
2012
Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA.
Neurobiology of disease.
47(3):416-27
[DOI] 10.1016/j.nbd.2012.04.015.
[PMID] 22579992.
2012
Enhanced hippocampal long-term potentiation and fear memory in Btbd9 mutant mice.
PloS one.
7(4)
[DOI] 10.1371/journal.pone.0035518.
[PMID] 22536397.
2012
Improved motor performance in Dyt1 ΔGAG heterozygous knock-in mice by cerebellar Purkinje-cell specific Dyt1 conditional knocking-out.
Behavioural brain research.
230(2):389-98
[DOI] 10.1016/j.bbr.2012.02.029.
[PMID] 22391119.
2011
Altered dendritic morphology of Purkinje cells in Dyt1 ΔGAG knock-in and purkinje cell-specific Dyt1 conditional knockout mice.
PloS one.
6(3)
[DOI] 10.1371/journal.pone.0018357.
[PMID] 21479250.
2011
Characterization of Atp1a3 mutant mice as a model of rapid-onset dystonia with parkinsonism.
Behavioural brain research.
216(2):659-65
[DOI] 10.1016/j.bbr.2010.09.009.
[PMID] 20850480.
2011
Motor deficits and decreased striatal dopamine receptor 2 binding activity in the striatum-specific Dyt1 conditional knockout mice.
PloS one.
6(9)
[DOI] 10.1371/journal.pone.0024539.
[PMID] 21931745.
2010
Chemical enhancement of torsinA function in cell and animal models of torsion dystonia.
Disease models & mechanisms.
3(5-6):386-96
[DOI] 10.1242/dmm.003715.
[PMID] 20223934.
2010
Earlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.
Journal of biochemistry.
148(4):459-66
[DOI] 10.1093/jb/mvq078.
[PMID] 20627944.
2009
A mental retardation gene, motopsin/neurotrypsin/prss12, modulates hippocampal function and social interaction.
The European journal of neuroscience.
30(12):2368-78
[DOI] 10.1111/j.1460-9568.2009.07029.x.
[PMID] 20092579.
2009
Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in Dyt1 DeltaGAG knock-in mice.
Neuroscience research.
65(3):228-35
[DOI] 10.1016/j.neures.2009.07.004.
[PMID] 19619587.
2008
Motor deficits and hyperactivity in cerebral cortex-specific Dyt1 conditional knockout mice.
Journal of biochemistry.
143(1):39-47
[PMID] 17956903.
2006
Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.
Proceedings of the National Academy of Sciences of the United States of America.
103(41):15254-9
[PMID] 17015831.
2006
Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism.
Biochemical and biophysical research communications.
341(3):691-6
[PMID] 16430861.
2006
Motor deficits and hyperactivity in Dyt1 knockdown mice.
Neuroscience research.
56(4):470-4
[PMID] 17046090.
2006
Myoclonus, motor deficits, alterations in emotional responses and monoamine metabolism in epsilon-sarcoglycan deficient mice.
Journal of biochemistry.
140(1):141-6
[PMID] 16815860.
2005
Exclusive paternal expression and novel alternatively spliced variants of epsilon-sarcoglycan mRNA in mouse brain.
FEBS letters.
579(21):4822-8
[PMID] 16099459.
2005
Generation and characterization of Dyt1 DeltaGAG knock-in mouse as a model for early-onset dystonia.
Experimental neurology.
196(2):452-63
[PMID] 16242683.
2003
Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase.
Journal of biochemistry.
133(5):607-14
[PMID] 12801912.
2002
A new organotypic culture of thyroid tissue maintains three-dimensional follicles with C cells for a long term.
Biochemical and biophysical research communications.
294(4):906-11
[PMID] 12061793.
2000
Air exposure promotes fibroblast growth with increased expression of mitogen-activated protein kinase cascade.
Biochemical and biophysical research communications.
270(3):961-6
[PMID] 10772933.
2000
Radiolabeled neuronal nitric oxide synthase inhibitors: synthesis, in vivo evaluation, and primate PET studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
41(8):1417-25
[PMID] 10945536.
1999
Bovine liver phosphoamidase as a protein histidine/lysine phosphatase.
Journal of biochemistry.
126(2):368-74
[PMID] 10423531.
1999
Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.
Synapse (New York, N.Y.).
32(1):44-50
[PMID] 10188637.
1999
GBR12909 attenuates amphetamine-induced striatal dopamine release as measured by [(11)C]raclopride continuous infusion PET scans.
Synapse (New York, N.Y.).
33(4):268-73
[PMID] 10421707.
1998
3-phosphohistidine and 6-phospholysine are substrates of a 56-kDa inorganic pyrophosphatase from bovine liver.
Archives of biochemistry and biophysics.
349(2):381-7
[PMID] 9448729.
1998
Dopamine transporter changes in neuropsychiatric disorders.
Advances in pharmacology (San Diego, Calif.).
42:219-23
[PMID] 9327883.
1997
Purification and characterization of hepatic inorganic pyrophosphatase hydrolyzing imidodiphosphate.
Archives of biochemistry and biophysics.
341(1):153-9
[PMID] 9143364.
1996
N(omega)-phosphoarginine phosphatase (17 kDa) and alkaline phosphatase as protein arginine phosphatases.
Journal of biochemistry.
119(4):719-24
[PMID] 8743574.
1993
The existence of pre-mature 16S rRNA species in plastid ribosomes.
FEBS letters.
327(1):29-31
[PMID] 8335092.
1992
Dopamine transporter imaging with novel, selective cocaine analogs.
Neuroreport.
3(11):969-72
[PMID] 1482766.
1992
Tobacco chloroplast ribosomes contain a homologue of E. coli ribosomal protein L28.
FEBS letters.
308(3):258-60
[PMID] 1505663.
1991
The chloroplast gene for ribosomal protein CL23 is functional in tobacco.
FEBS letters.
281(1-2):64-6
[PMID] 1707833.
1990
Chloroplast ribosomal protein L32 is encoded in the chloroplast genome.
FEBS letters.
276(1-2):88-90
[PMID] 2265719.
1988
Nucleotide sequence of the gene coding for cytochrome oxidase subunit I from the thermophilic bacterium PS3.
Journal of biochemistry.
103(4):606-10
[PMID] 2844737.
Grants
Jun 2018
– Dec 2021
Chemogenetic modulation of striatal cholinergic interneurons in DYT1 dystonia
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Contact Details
Phones:
- Business:
- (352) 273-6631
Emails:
- Business:
- fyokoi@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100236
GAINESVILLE FL 32610 - Business Street:
-
PO Box 100236
GAINESVILLE FL 32610