Neurocritical Care

There is an unmet need in advancing therapeutic approaches in neurocritical care. This field is in its infancy of implementation of translational research, and most of clinical practice is led by expert opinion-derived guidelines informed by studies with low quality of evidence. The Neurocritical Care division at the University of Florida is committed to bringing innovative and creative perspectives to complex scientific questions, and engaging in transdisciplinary team science to stimulate new lines of research bridging the frontiers of neuroscience, anesthesia, critical care medicine, neurology, cardiology, traumatology and neurosurgery.

The UF Neurocritical Care unit is an enrolling site for multiple acute brain injury multicenter studies that include:

  • BOOST III – Brain Oxygen Optimization in Severe TBI Phase-3
  • CATCH – A proof of concept study to evaluate the administration of CN-105 in participants with Acute supratentorial intraCerebral Hemorrhage
  • Critical Care EEG Monitoring Research Consortium – Cardiac Arrest Taskforce
  • CHARM – Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction
  • INTREPID – Impact of Fever Prevention in Brain Injured Patients
  • PILLAR-XT – Extracorporeal Filtration of Subarachnoid Hemorrhage via Spinal Catheter Extension

The Cardiac Arrest lab directed by Dr. Maciel aims at improving outcomes of cardiac arrest survivors by refining neuroprognostication and decreasing the overall hypoxic-ischemic brain injury burden by identifying mechanisms of injury that can be targeted in novel therapies in a partnership with the Neuroscience and Emergency Medicine departments.

Additionally, in coordination with the Neurosurgery department, the Neurocritical Care division at UF maintains a comprehensive registry of patients with acquired devastating neurological injuries including subdural hematoma, subarachnoid hemorrhage, status epilepticus, cardiac arrest, moya-moya and traumatic brain injury. This registry will continue to expand and allow for a better understanding of mechanisms of secondary brain injury and lead to tailored neurocritical care management to improve outcomes.

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