The goal of this therapeutic trial is to analyze the efficacy, feasibility, and safety of pterygopalatine fossa blocks (PPF-blocks) as an innovative opioid-sparing approach in alleviating headaches in patients with aneurysmal subarachnoid hemorrhage (SAH). 


Severe headaches are the hallmark symptom of SAH, and they persist for months or even years after SAH, resulting in anxiety, stress, sleep disorders, and increased readmissions. Despite their unendurable severity and high prevalence, multimodal management plans and novel treatment techniques have not been investigated, making escalating doses of opioids as the mainstay guideline-recommended treatment. This poses catastrophic problems like opioid addiction, dependence, and tolerance in the patients. BLOCK-SAH is a frontier prospective trial where PPF-blocks are administered in patients with aneurysmal SAH to assess their effect in relieving headaches and decreasing opioids requirements for headache management while staying on the lookout for any adverse effects. If PPF-blocks are proven safe and effective, these blocks will not only reduce the prevalence of headaches and the need for opioids in this patient population, but also open gateways to investigating the utility of these blocks in other neurocritically ill patients. 

About our Study

Sites and Investigators

BLOCK-SAH is a multi-site clinical trial being conducted at 12 neuro-intensive care units across the United States together with the data coordinating center from New York University and clinical coordinating center from the Massachusetts General Hospital.

Neuromedicine Hospital

Study Overview

During the screening period participants are assessed for their eligibility in the trial. Enrolled participants enter the intervention phase where they receive either the active block or saline/placebo. All participants are closely monitored for headaches and adverse reactions.

Study overview


If you or a family member would like to participate in the trial, please feel free to contact us. A member of the research team will contact you to address your questions and concerns.


Our moments

Picture Gallery

We have kept a record of our key learning moments, fun activities, and accomplishments in the form of pictures. Through this gallery, we invite you to cruise through our voyage in this groundbreaking trial.

The team

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