Prodip K Bose

Prodip K Bose, MD, PhD

Associate Professor Of Anesthesiology, Neurology, & Physiological Sciences; Director, MRI & Translational Neurotrauma Rehabilitation Lab; Associate Director, Brain Rehabilitation Research Center

Department: MD-ANESTHESIOLOGY-GENERAL
Business Phone: (352) 376-1611
Business Email: pbose@anest.ufl.edu

About Prodip K Bose

Prodip K. Bose, MD, PhD, joined us as an Associate Professor in 2020. He currently holds joint appointments as an Associate Professor in the Department of Neurology in the College of Medicine and McKnight Brain Institute and as an Associate Professor in the Department of Physiological Sciences in the College of Veterinary Medicine.

In addition, Dr. Bose is Director of the MRI and Translational Neurotrauma Rehabilitation Laboratory at the Malcom Randall VA Medical Center. He serves as Associate Director of the Brain Rehabilitation Research Center, a national center of the VA Rehabilitation Research & Development; Deputy Associate Chief of Staff/Research & Development for the Veterinary Medical Unit, North Florida/South Georgia Veterans Health System; and a member of the Editorial Board of the Neural Regeneration Research journal.

Dr. Bose, whose main areas of research are spinal cord injury, traumatic brain injury, and stroke, is also University of Florida Graduate Faculty in the College of Medicine Interdisciplinary Program and a member of several committees of the VA health system.

He earned his medical degree from the University of Dhaka in Bangladesh and did a fellowship in Neurology at Case Western Reserve University School of Medicine and Northeastern Ohio Universities College of Medicine. His PhD in Neuroscience was awarded by the University of Hong Kong.

Dr. Bose has contributed numerous peer-reviewed manuscripts, abstracts, and conference proceedings to his field and is currently involved as both a principal investigator and co-principal investigator on six active research grants.

Accomplishments

Exceptional Performance and Outstanding Contributor
2016-2018 · North Florida/South Georgia Veterans Affairs Health System, Malcom Randall VAMC
Outstanding and Dedicated Service Award
2016 · Bangladesh Medical Association of North America
Member of the Editorial Board
2015-2020 · Journal Neural Regeneration Research
C.E. Cornelius Young Investigator Award
2014 · College of Veterinary Medicine, University of Florida
Visiting Professor, Department of Neurosurgery
2013 · University of Iowa, Carver College of Medicine
Honorary Faculty Member
2012-2020 · Phi Zeta Society, Upsilon Chapter
Technology Innovator
2012 · Office of Technology Licensing, University of Florida (US patent number: 9,421,141 (UF No.: 13760)
Outstanding Scientist Award
2010 · World Federation for Neurorehabilitation
Review member
2009-2020 · Department of Veterans Affairs Rehabilitation Research and Development Service
Excellence in Teaching and Humanity Award
2007 · Bahai’s Student Association, University of Florida and Gainesville

Research Profile

Recently, attention has been given to develop a research program in the area of iron cheletor therapies aiming at to reduce neuro-inflammation and enhance neuroregeneration following neurotrauma (TBI and SCI), stroke, and Parkinson’s disease. The inflammatory burden initiated by injury/disease is further increased by iron derived from micro-bleeds which is known to act as a powerful promoter of chronic inflammation. Focus has been given to cellular and molecular neurobiology related to therapies-induced recovery of disabilities (spasticity/rigidity-motor, anxiety-like behavior, cognitive, balance and pain problems). Long-term focus of my laboratory research has been to understand the molecular-physiological-through-behavioral neurobiology of motor, sensory and cognitive plasticity following pharmacotherapy and neurorehabilitation using preclinical (rodent) models of neurotrauma (spinal cord, traumatic brain injuries, and stoke), and neurodegenerative/neuro-autoimmune diseases (e.g., PD, MS, ALS). Research focus has been directed to mechanism-based research studies that involve the development and testing of innovative translational targeted pharmacological therapies in conjunction to other complementary therapies (e.g., programmed locomotor exercise, transcranial magnetic stimulation, electrical stimulation on acupuncture points, stem cell and gene therapy) aimed at inducing guided plasticity and neuroregeneration, and ultimately reducing disabilities. A through drug toxicological studies using behavioral, physiological and histological measures are integral part of this therapeutic initiative.

Research program in the Bose Laboratory is supported by funding from US Department of Veterans Affair (list is not included here under funding), NIH, and several other funding agencies.

Open Researcher and Contributor ID (ORCID)

0000-0002-1378-3644

Publications

2021
Compensatory functional connectome changes in a rat model of traumatic brain injury
Brain communications. 3(4) [DOI] 10.1093/braincomms/fcab244. [PMID] 34729482.
2020
Altered monoaminergic levels, spasticity, and balance disability following repetitive blast-induced traumatic brain injury in rats.
Brain research. 1747 [DOI] 10.1016/j.brainres.2020.147060. [PMID] 32828734.
2020
Effect of Simultaneous Combined Treadmill Training and Magnetic Stimulation on Spasticity and Gait Impairments after Cervical Spinal Cord Injury.
Journal of neurotrauma. 37(18):1999-2013 [DOI] 10.1089/neu.2019.6961. [PMID] 32340533.
2020
Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.
Journal of neuroscience research. 98(5):843-868 [DOI] 10.1002/jnr.24564. [PMID] 31797423.
2020
Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
Metabolism: clinical and experimental. 110 [DOI] 10.1016/j.metabol.2020.154297. [PMID] 32562798.
2019
Longitudinal Examination of Bone Loss in Male Rats After Moderate-Severe Contusion Spinal Cord Injury.
Calcified tissue international. 104(1):79-91 [DOI] 10.1007/s00223-018-0471-8. [PMID] 30218117.
2017
Mild and Mild-to-Moderate Traumatic Brain Injury-Induced Significant Progressive and Enduring Multiple Comorbidities.
Journal of neurotrauma. 34(16):2456-2466 [DOI] 10.1089/neu.2016.4851. [PMID] 28376701.
2017
Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model: mechanisms underlying orofacial allodynias and headache.
Neural regeneration research. 12(6):981-986 [DOI] 10.4103/1673-5374.208594. [PMID] 28761433.
2016
Closed-Head TBI Model of Multiple Morbidity.
Methods in molecular biology (Clifton, N.J.). 1462:521-36 [DOI] 10.1007/978-1-4939-3816-2_28. [PMID] 27604736.
2016
Prolonged hippocampal cell death following closed-head traumatic brain injury in rats.
Neuroreport. 27(10):724-9 [DOI] 10.1097/WNR.0000000000000598. [PMID] 27213933.
2016
Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI).
Neuropharmacology. 107:27-39 [DOI] 10.1016/j.neuropharm.2016.03.016. [PMID] 26972829.
2015
Sclerostin inhibition prevents spinal cord injury-induced cancellous bone loss.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30(4):681-9 [DOI] 10.1002/jbmr.2396. [PMID] 25359699.
2014
Bone Loss in a New Rodent Model Combining Spinal Cord Injury and Cast Immobilization
Journal of Musculoskeletal & Neuronal Interactions. 14(3):255-266
2014
Dose Response Effects of Acute Admistritation of Intrathecal Baclofen (Itb) On Tbi-Induced Spasticity
Journal of Neurotrauma. 31(12)
2014
Effect of combined treadmill training and magnetic stimulation on spasticity and gait impairments after cervical spinal cord injury.
Journal of neurotrauma. 31(12):1088-106 [DOI] 10.1089/neu.2013.3096. [PMID] 24552465.
2014
Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury.
Journal of neurotrauma. 31(9):834-45 [DOI] 10.1089/neu.2013.3155. [PMID] 24378197.
2014
Therapeutic Tms Reduces Tbi Spasticity, Anxiety, and Pain
Journal of Neurotrauma. 31(12)
2013
Closed Head Traumatic Brain Injury (Ctbi)-Induced Multiple Disabilities (Motor, Cognitive, Anxiety) Improved By Programmed Therapeutic Exercise
Journal of Neurotrauma. 30:A52-A53
2013
Effects of acute intrathecal baclofen in an animal model of TBI-induced spasticity, cognitive, and balance disabilities.
Journal of neurotrauma. 30(13):1177-91 [DOI] 10.1089/neu.2012.2740. [PMID] 23268729.
2013
Hindlimb muscle morphology and function in a new atrophy model combining spinal cord injury and cast immobilization.
Journal of neurotrauma. 30(3):227-35 [DOI] 10.1089/neu.2012.2504. [PMID] 22985272.
2013
Subchronic Intrathecal Baclofen (Itb) Treatment in An Animal Model of Tbi-Induced Spasticity
Journal of Neurotrauma. 30:A58-A59
2013
Testosterone Treatment Prevents Spinal Cord Injury-Induced Bone Loss in Male Rats
The FASEB's Journal. 27
2013
White Matter Integrity After Severe Contusion Spinal Cord Injury Under Different Levels of Activity
Journal of Neurotrauma. 30:A116-A117
2012
Altered patterns of reflex excitability, balance, and locomotion following spinal cord injury and locomotor training.
Frontiers in physiology. 3 [DOI] 10.3389/fphys.2012.00258. [PMID] 22934014.
2012
Mri and Dti Characterization of Spinal Cord Severe Contusion Injury in the Rat
The FASEB's Journal. 26
2012
Similarities and Dissimilarities of Two Experimental Models of Tbi (Closed Head and Blast Tbi) in Long-Term Disabilities: Spasticity, Cognitive and Synaptic Function, Balance, Anxiety, and Pain Related Behaviors
Journal of Neurotrauma. 29:A56-A57
2011
A Combination of Treadmill Training and Magnetic Stimulation Improved Spasticity and Gait Disabilities Following Cervical Spinal Cord Injury (C-Sci)
Journal of Neurotrauma. 28
2011
A New Rat Model of Spinal Cord Injury Without Muscle Reloading: Morphological and Functional Assessment By Mr Imaging and (31)P Spectroscopy
Journal of Neurotrauma. 28
2011
Experimental Model of Closed Head Tbi (Ch-Tbi) To Study the Neurobiology and Pathophysiology of Long Term Disabilities: Spasticity, Cognitive, Balance, Anxiety, and Pain Related Behaviors
Journal of Neurotrauma. 28
2011
Intrathecal Baclofen (Itb) Initiaed in Acute Traumatic Brain Injury (Tbi) More Effectively Reduced Spasticity Than When Initiated in the Subchronic Setting
Journal of Neurotrauma. 28
2010
Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats.
European journal of applied physiology. 109(4):709-20 [DOI] 10.1007/s00421-010-1392-z. [PMID] 20213470.
2010
The Effect of Igf-I Overexpression in Skeletal Muscle Following Spinal Cord Injury and Locomotor Training
Medicine and Science in Sports and Exercise. 42
2009
Anxiety and Pain Behavioural Disabilities Following Mild/Moderate Closed Head Tbi in the Rat
Journal of Neurotrauma. 26
2009
Spasticity and Gait Disabilities Following Low Cervical Spinal Cord Contusion Injury (C-Sci)
Journal of Neurotrauma. 26
2009
Spasticity and Gait Disabilities Following Low Cervical Spinal Cord Contusion Injury (C-Sci)
Journal of Neurotrauma. 26
2008
A longitudinal study of skeletal muscle following spinal cord injury and locomotor training.
Spinal cord. 46(7):488-93 [DOI] 10.1038/sj.sc.3102169. [PMID] 18283294.
2008
A Potential New Therapy To Alleviate Experimental Autoimmune Encephalomyelitis Symptoms: An Animal Model of Multiple Sclerosis
Multiple Sclerosis Journal. 14
2008
Acute, Subchronic, Or Chronic Treatments Differentially Influence Development of Science Spasticity
Journal of Neurotrauma. 25
2008
Spasticity and Gait Disabilities Induced By Cervical Spinal Cord Contusion Injury (C-Sci)
Journal of Neurotrauma. 25
2006
Changes in muscle T2 relaxation properties following spinal cord injury and locomotor training.
European journal of applied physiology. 97(3):355-61 [PMID] 16770473.
View on: PubMed
2006
Changes in soleus muscle function and fiber morphology with one week of locomotor training in spinal cord contusion injured rats.
Journal of neurotrauma. 23(11):1671-81 [PMID] 17115912.
View on: PubMed
2005
Morphological changes of the soleus motoneuron pool in chronic midthoracic contused rats.
Experimental neurology. 191(1):13-23 [PMID] 15589508.
View on: PubMed
2002
Chronic intrathecal baclofen treatment and withdrawal: I. Changes in ankle torque and hind limb posture in normal rats.
Journal of neurotrauma. 19(7):875-86 [PMID] 12184857.
View on: PubMed
2002
Velocity-dependent ankle torque in rats after contusion injury of the midthoracic spinal cord: time course.
Journal of neurotrauma. 19(10):1231-49 [PMID] 12427331.
View on: PubMed
2001
Scientific basis of spasticity: insights from a laboratory model.
Journal of child neurology. 16(1):2-9 [PMID] 11225952.
View on: PubMed
1999
Effects of assisted feeding on Wobbler mouse motoneuron disease and on serotonergic and peptidergic sprouting in the cervical spinal ventral horn.
Brain research bulletin. 48(4):429-39 [PMID] 10357076.
View on: PubMed
1999
Increase in fiber density for immunoreactive serotonin, substance P, enkephalin and thyrotropin-releasing hormone occurs during the early presymptomatic period of motoneuron disease in Wobbler mouse spinal cord ventral horn.
Neuroscience letters. 260(3):196-200 [PMID] 10076901.
View on: PubMed
1998
A novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days old.
Brain research. 813(2):334-42 [PMID] 9838183.
View on: PubMed

Grants

Sep 2021 ACTIVE
Functionalized Enzyme Treatments for Dual-Targeting of Inflammation in Spinal Cord Injury
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Mar 2021 ACTIVE
Preservation of spinal cord tissue resulting from Ischemia following Aortic Surgery: creation of a clinically relevant rodent model and testing of a novel oxygen release therapeutic
Role: Principal Investigator
Funding: UF FOUNDATION
Mar 2021 ACTIVE
Preservation of spinal cord tissue resulting from Ischemia following Aortic Surgery: creation of a clinically relevant rodent model and testing of a novel oxygen release therapeutic
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2020 ACTIVE
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2020 – Jul 2021
IPA Jiamei Hou
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2020 ACTIVE
VA IPA – Shigeharu Tsuda
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2019 – Jul 2020
IPA for Jaimai Hou
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2019 – Jun 2020
IPA for Shigeharu Tsuda
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2018 – Jul 2019
IPA Hou
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Apr 2018 – Mar 2021
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2017 – Apr 2019
IPA Shigeharu Tsuda
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2017 – May 2018
IPA Hou 1fte
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
May 2017 – Sep 2017
IPA for Tsuda 1FTE
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2016 – Sep 2018
IPA-Golam Mustafa
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2015 – Sep 2016
IPA FOR GOLAM MUSTAFA
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2014 – May 2016
IPA for Shigeharu Tsuda
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2013 – Jun 2019
Brain injury: Development and testing of a laboratory model.
Role: Principal Investigator
Funding: MEDTRONIC INC

Patents

Issued August 2016
Systems and Methods for Promoting Locomotion and Facilitating Exercise
#9,421,141

Education

PhD, Neuroscience
1998 · University of Hong Kong
Neurology Fellowship
1994 · Case Western Reserve University/Northeastern Ohio Universities
Medical Degree
1990 · University of Dhaka, Bangladesh

Teaching Profile

Courses Taught
2018
BME7980 Research for Doctoral Dissertation
2015-2016
VEM5110 Animal Systems 1

Contact Details

Phones:
Business:
(352) 376-1611
Emails: