Christopher R Butson, PhD
Prof
Department:
MD-NEUROLOGY-MOVEMENT DISORDER
Business Email:
butsonc@ufl.edu
About Christopher R Butson
Dr. Butson received a B.S. in Mechanical Engineering from the University of Maryland, M.S. in Electrical Engineering from George Washington University and Ph.D. in Biomedical Engineering from the University of Utah. He completed post-doctoral training at the Cleveland Clinic and was a faculty member at the Medical College of Wisconsin from 2008-2014. From 2014 through 2020 he led a research laboratory in the Scientific Computing & Imaging (SCI) Institute and the Department of Biomedical Engineering at the University of Utah. Starting in 2021 he is a Professor of Neurology and the Fixel Endowed Chair of Neurotherapeutics at the University of Florida. The research focus of his lab is neuromodulation, specifically therapeutic and diagnostic brain stimulation. He holds 10 patents in this area, some of which were licensed to Intelect Medical, a spinoff company that was sold to Boston Scientific in 2011. He is the CEO of a consulting company that specializes in neurostimulation devices and neuromodulation therapy. He is an active member of the Society for Neuroscience (SFN), the Institute of Electrical & Electronics Engineers (IEEE), the Engineering in Medicine & Biology Society (EMBS), the International Parkinson and Movement Disorder Society (MDS) and the American Society for Engineering Education (ASEE).
Accomplishments
Mentor to Daria N. Anderson Winner of Outstanding Dissertation Award to Biomedical Engineering graduate student
2020
·
University of Utah College of Engineering
Faculty with >$1M in Research Expenditures
2019
·
University of Utah College of Engineering
Faculty with >$1M in Research Expenditures
2018
·
University of Utah College of Engineering
Only faculty member in the College of Engineering (>200 faculty) in the highest category of achievement for both teaching and research funding
2018
·
University of Utah College of Engineering
Top Graduate School Teacher
2018
·
University of Utah College of Engineering
Faculty with >$1M in Research Expenditures
2017
·
University of Utah College of Engineering
Only faculty member in the College of Engineering (>200 faculty) in the highest category of achievement for both teaching and research funding
2017
·
University of Utah College of Engineering
Top Graduate School Teacher
2017
·
University of Utah College of Engineering
Research Profile
Open Researcher and Contributor ID (ORCID)
Publications
2024
Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation.
Epilepsia.
[DOI] 10.1111/epi.17938.
[PMID] 38517356.
2024
Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes.
Brain : a journal of neurology.
147(2):521-531
[DOI] 10.1093/brain/awad343.
[PMID] 37796038.
2023
Interactive mobile application for Parkinson’s disease deep brain stimulation (MAP DBS): An open-label, multicenter, randomized, controlled clinical trial.
Parkinsonism & related disorders.
109
[DOI] 10.1016/j.parkreldis.2023.105346.
[PMID] 36966051.
2023
Neurosurgical lesioning for Tourette syndrome – Authors’ reply.
The Lancet. Neurology.
22(4):292-293
[DOI] 10.1016/S1474-4422(23)00079-0.
[PMID] 36931795.
2023
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study.
Nature medicine.
29(12):3162-3174
[DOI] 10.1038/s41591-023-02638-4.
[PMID] 38049620.
2023
Tourette syndrome: clinical features, pathophysiology, and treatment.
The Lancet. Neurology.
22(2):147-158
[DOI] 10.1016/S1474-4422(22)00303-9.
[PMID] 36354027.
2022
Editorial: Deep Brain Stimulation Think Tank: Updates in Neurotechnology and Neuromodulation, Volume II.
Frontiers in human neuroscience.
16
[DOI] 10.3389/fnhum.2022.912730.
[PMID] 35721359.
2022
Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.
Frontiers in neurology.
13
[DOI] 10.3389/fneur.2022.825178.
[PMID] 35356461.
2022
Patient-specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy.
Epilepsia.
63(8):2037-2055
[DOI] 10.1111/epi.17298.
[PMID] 35560062.
2022
Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury.
Frontiers in human neuroscience.
16
[DOI] 10.3389/fnhum.2022.813387.
[PMID] 35308605.
2021
Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.
Biological psychiatry. Cognitive neuroscience and neuroimaging.
6(10):961-972
[DOI] 10.1016/j.bpsc.2020.11.005.
[PMID] 33536144.
2021
Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder.
Biological psychiatry.
90(10):678-688
[DOI] 10.1016/j.biopsych.2021.07.010.
[PMID] 34482949.
2021
Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience.
15
[DOI] 10.3389/fnhum.2021.765150.
[PMID] 34658825.
2021
Functional Hyperconnectivity and Task-Based Activity Changes Associated With Neuropathic Pain After Spinal Cord Injury: A Pilot Study.
Frontiers in neurology.
12
[DOI] 10.3389/fneur.2021.613630.
[PMID] 34177753.
2021
Home Health Management of Parkinson Disease Deep Brain Stimulation: A Randomized Clinical Trial.
JAMA neurology.
78(8):972-981
[DOI] 10.1001/jamaneurol.2021.1910.
[PMID] 34180949.
2021
Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience.
15
[DOI] 10.3389/fnhum.2021.644593.
[PMID] 33953663.
2021
Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-02270-7.
[PMID] 34845232.
2021
Validating Patient-Specific Finite Element Models of Direct Electrocortical Stimulation.
Frontiers in neuroscience.
15
[DOI] 10.3389/fnins.2021.691701.
[PMID] 34408621.
2020
A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy.
Brain stimulation.
13(5):1232-1244
[DOI] 10.1016/j.brs.2020.06.002.
[PMID] 32504827.
2020
Activation robustness with directional leads and multi-lead configurations in deep brain stimulation.
Journal of neural engineering.
17(2)
[DOI] 10.1088/1741-2552/ab7b1d.
[PMID] 32116233.
2020
Interactive computation and visualization of deep brain stimulation effects using Duality.
Computer methods in biomechanics and biomedical engineering. Imaging & visualization.
8(1):3-14
[DOI] 10.1080/21681163.2018.1484817.
[PMID] 32742820.
2020
Neural selectivity, efficiency, and dose equivalence in deep brain stimulation through pulse width tuning and segmented electrodes.
Brain stimulation.
13(4):1040-1050
[DOI] 10.1016/j.brs.2020.03.017.
[PMID] 32278715.
2020
Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome.
Brain : a journal of neurology.
143(8):2607-2623
[DOI] 10.1093/brain/awaa188.
[PMID] 32653920.
2020
The International Neuromodulation Registry: An Informatics Framework Supporting Cohort Discovery and Analysis.
Frontiers in neuroinformatics.
14
[DOI] 10.3389/fninf.2020.00036.
[PMID] 33071769.
2020
Tract-based analysis of target engagement by subcallosal cingulate deep brain stimulation for treatment resistant depression.
Brain stimulation.
13(4):1094-1101
[DOI] 10.1016/j.brs.2020.03.006.
[PMID] 32417668.
2019
A retrospective evaluation of automated optimization of deep brain stimulation parameters.
Journal of neural engineering.
16(6)
[DOI] 10.1088/1741-2552/ab35b1.
[PMID] 31344689.
2019
A statistical framework for quantification and visualisation of positional uncertainty in deep brain stimulation electrodes.
Computer methods in biomechanics and biomedical engineering. Imaging & visualization.
7(4):438-449
[DOI] 10.1080/21681163.2018.1523750.
[PMID] 31186994.
2019
Anodic stimulation misunderstood: preferential activation of fiber orientations with anodic waveforms in deep brain stimulation.
Journal of neural engineering.
16(1)
[DOI] 10.1088/1741-2552/aae590.
[PMID] 30275348.
2019
Effect of STN DBS on vesicular monoamine transporter 2 and glucose metabolism in Parkinson’s disease.
Parkinsonism & related disorders.
64:235-241
[DOI] 10.1016/j.parkreldis.2019.04.006.
[PMID] 31053531.
2019
Evaluation of methodologies for computing the deep brain stimulation volume of tissue activated.
Journal of neural engineering.
16(6)
[DOI] 10.1088/1741-2552/ab3c95.
[PMID] 31426036.
2019
Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study.
Journal of neurology, neurosurgery, and psychiatry.
90(10):1078-1090
[DOI] 10.1136/jnnp-2019-320379.
[PMID] 31129620.
2019
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction.
Frontiers in neuroscience.
13
[DOI] 10.3389/fnins.2019.00531.
[PMID] 31231178.
2019
Interleaved deep brain stimulation for dyskinesia management in Parkinson’s disease.
Movement disorders : official journal of the Movement Disorder Society.
34(11):1722-1727
[DOI] 10.1002/mds.27839.
[PMID] 31483534.
2019
The μDBS: Multiresolution, Directional Deep Brain Stimulation for Improved Targeting of Small Diameter Fibers.
Frontiers in neuroscience.
13
[DOI] 10.3389/fnins.2019.01152.
[PMID] 31736693.
2018
Deep brain stimulation for the treatment of disorders of consciousness and cognition in traumatic brain injury patients: a review.
Neurosurgical focus.
45(2)
[DOI] 10.3171/2018.5.FOCUS18168.
[PMID] 30064315.
2018
Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes.
Journal of neural engineering.
15(2)
[DOI] 10.1088/1741-2552/aaa14b.
[PMID] 29235446.
2018
Pedunculopontine nucleus deep brain stimulation in Parkinson’s disease: A clinical review.
Movement disorders : official journal of the Movement Disorder Society.
33(1):10-20
[DOI] 10.1002/mds.27098.
[PMID] 28960543.
2018
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models.
Journal of visualized experiments : JoVE.
(138)
[DOI] 10.3791/57292.
[PMID] 30148495.
2016
Longitudinal Changes in Depressive Circuitry in Response to Neuromodulation Therapy.
Frontiers in neural circuits.
10
[DOI] 10.3389/fncir.2016.00050.
[PMID] 27524960.
2016
Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.
Frontiers in integrative neuroscience.
10
[PMID] 27920671.
2016
Robust modulation of arousal regulation, performance, and frontostriatal activity through central thalamic deep brain stimulation in healthy nonhuman primates.
Journal of neurophysiology.
116(5):2383-2404
[DOI] 10.1152/jn.01129.2015.
[PMID] 27582298.
2016
Visualization for Understanding Uncertainty in Activation Volumes for Deep Brain Stimulation.
Eurographics/IEEE VGTC Symposium on Visualization : EUROVIS : [proceedings]. Eurographics/IEEE VGTC Symposium on Visualization.
2016:37-41
[DOI] 10.2312/eurovisshort.20161158.
[PMID] 28217766.
2015
Antidepressant-like Effects of Medial Forebrain Bundle Deep Brain Stimulation in Rats are not Associated With Accumbens Dopamine Release.
Brain stimulation.
8(4):708-13
[DOI] 10.1016/j.brs.2015.02.007.
[PMID] 25835354.
2015
Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What’s in the Pipeline.
The International journal of neuroscience.
125(7):475-85
[DOI] 10.3109/00207454.2014.999268.
[PMID] 25526555.
2015
Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation.
Neuromodulation : journal of the International Neuromodulation Society.
18(8):694-704
[DOI] 10.1111/ner.12296.
[PMID] 25953411.
2015
The Use of Stimulation Field Models for Deep Brain Stimulation Programming.
Brain stimulation.
8(5):976-8
[DOI] 10.1016/j.brs.2015.06.005.
[PMID] 26358487.
2014
Acute and Chronic Mood and Apathy Outcomes from a randomized study of unilateral STN and GPi DBS.
PloS one.
9(12)
[DOI] 10.1371/journal.pone.0114140.
[PMID] 25469706.
2014
Anatomical targets associated with abrupt versus gradual washout of subthalamic deep brain stimulation effects on bradykinesia.
PloS one.
9(8)
[DOI] 10.1371/journal.pone.0099663.
[PMID] 25098453.
2014
Coordinate-based lead location does not predict Parkinson’s disease deep brain stimulation outcome.
PloS one.
9(4)
[DOI] 10.1371/journal.pone.0093524.
[PMID] 24691109.
2014
Deep brain stimulation in rats: different targets induce similar antidepressant-like effects but influence different circuits.
Neurobiology of disease.
71:205-14
[DOI] 10.1016/j.nbd.2014.08.007.
[PMID] 25131446.
2013
Evaluation of Interactive Visualization on Mobile Computing Platforms for Selection of Deep Brain Stimulation Parameters.
IEEE transactions on visualization and computer graphics.
19(1):108-17
[DOI] 10.1109/TVCG.2012.92.
[PMID] 22450824.
2013
Holographically patterned activation using photo-absorber induced neural-thermal stimulation.
Journal of neural engineering.
10(5)
[DOI] 10.1088/1741-2560/10/5/056004.
[PMID] 23902876.
2013
Management of deep brain stimulator battery failure: battery estimators, charge density, and importance of clinical symptoms.
PloS one.
8(3)
[DOI] 10.1371/journal.pone.0058665.
[PMID] 23536810.
2013
Potential for unreliable interpretation of EEG recorded with microelectrodes.
Epilepsia.
54(8):1391-401
[DOI] 10.1111/epi.12202.
[PMID] 23647099.
2013
The role of electrode location and stimulation polarity in patient response to cortical stimulation for major depressive disorder.
Brain stimulation.
6(3):254-60
[DOI] 10.1016/j.brs.2012.07.001.
[PMID] 22819247.
2012
Computational models of neuromodulation.
International review of neurobiology.
107:5-22
[DOI] 10.1016/B978-0-12-404706-8.00002-4.
[PMID] 23206676.
2012
Signal distortion from microelectrodes in clinical EEG acquisition systems.
Journal of neural engineering.
9(5)
[PMID] 22878608.
2011
Epidural cortical stimulation of the left dorsolateral prefrontal cortex for refractory major depressive disorder.
Neurosurgery.
69(5):1015-29; discussion 1029
[DOI] 10.1227/NEU.0b013e318229cfcd.
[PMID] 21709597.
2011
Probabilistic analysis of activation volumes generated during deep brain stimulation.
NeuroImage.
54(3):2096-104
[DOI] 10.1016/j.neuroimage.2010.10.059.
[PMID] 20974269.
2011
Selective neural activation in a histologically derived model of peripheral nerve.
Journal of neural engineering.
8(3)
[DOI] 10.1088/1741-2560/8/3/036009.
[PMID] 21478574.
2011
Spectral signal space projection algorithm for frequency domain MEG and EEG denoising, whitening, and source imaging.
NeuroImage.
56(1):78-92
[DOI] 10.1016/j.neuroimage.2011.02.002.
[PMID] 21315157.
2010
Patient-specific models of deep brain stimulation: influence of field model complexity on neural activation predictions.
Brain stimulation.
3(2):65-7
[DOI] 10.1016/j.brs.2010.01.003.
[PMID] 20607090.
2009
Automated 3-dimensional brain atlas fitting to microelectrode recordings from deep brain stimulation surgeries.
Stereotactic and functional neurosurgery.
87(4):229-40
[DOI] 10.1159/000225976.
[PMID] 19556832.
2009
Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes.
Journal of neurology, neurosurgery, and psychiatry.
80(6):659-66
[DOI] 10.1136/jnnp.2007.126219.
[PMID] 18403440.
2009
Experimental and theoretical characterization of the voltage distribution generated by deep brain stimulation.
Experimental neurology.
216(1):166-76
[DOI] 10.1016/j.expneurol.2008.11.024.
[PMID] 19118551.
2009
Neuromagnetic source imaging of abnormal spontaneous activity in tinnitus patient modulated by electrical cortical stimulation.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference.
2009:1940-4
[DOI] 10.1109/IEMBS.2009.5333457.
[PMID] 19964017.
2008
Current steering to control the volume of tissue activated during deep brain stimulation.
Brain stimulation.
1(1):7-15
[DOI] 10.1016/j.brs.2007.08.004.
[PMID] 19142235.
2008
Mechanisms of noise-induced improvement in light-intensity encoding in Hermissenda photoreceptor network.
Journal of neurophysiology.
99(1):155-65
[PMID] 18003872.
2008
Random noise paradoxically improves light-intensity encoding in Hermissenda photoreceptor network.
Journal of neurophysiology.
99(1):146-54
[PMID] 18003873.
2007
Cicerone: stereotactic neurophysiological recording and deep brain stimulation electrode placement software system.
Acta neurochirurgica. Supplement.
97(Pt 2):561-7
[PMID] 17691348.
2007
Computational analysis of deep brain stimulation.
Expert review of medical devices.
4(5):615-22
[PMID] 17850196.
2007
Differences among implanted pulse generator waveforms cause variations in the neural response to deep brain stimulation.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology.
118(8):1889-94
[PMID] 17581776.
2007
Patient-specific analysis of the volume of tissue activated during deep brain stimulation.
NeuroImage.
34(2):661-70
[PMID] 17113789.
2007
StimExplorer: deep brain stimulation parameter selection software system.
Acta neurochirurgica. Supplement.
97(Pt 2):569-74
[PMID] 17691349.
2006
Computational analysis of subthalamic nucleus and lenticular fasciculus activation during therapeutic deep brain stimulation.
Journal of neurophysiology.
96(3):1569-80
[PMID] 16738214.
2006
Optimizing deep brain stimulation parameter selection with detailed models of the electrode-tissue interface.
Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.
2006:893-5
[PMID] 17946871.
2006
Predicting the effects of deep brain stimulation with diffusion tensor based electric field models.
Medical image computing and computer-assisted intervention : MICCAI … International Conference on Medical Image Computing and Computer-Assisted Intervention.
9(Pt 2):429-37
[PMID] 17354801.
2006
Role of electrode design on the volume of tissue activated during deep brain stimulation.
Journal of neural engineering.
3(1):1-8
[PMID] 16510937.
2006
Sources and effects of electrode impedance during deep brain stimulation.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology.
117(2):447-54
[PMID] 16376143.
2006
Subthalamic nucleus deep brain stimulation: accurate axonal threshold prediction with diffusion tensor based electric field models.
Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.
2006:1240-3
[PMID] 17946452.
2005
Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulation.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology.
116(10):2490-500
[DOI] 10.1016/j.clinph.2005.06.023.
[PMID] 16125463.
Grants
Sep 2021
ACTIVE
Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2021
ACTIVE
Thalamic Stimulation to Prevent Impaired Consciousness in Epilepsy
Role: Principal Investigator
Funding: YALE UNIV
via NATL INST OF HLTH NINDS
Jun 2021
ACTIVE
Thalamocortical responsive neurostimulation for the treatment of Lennox-Gastaut syndrome
Role: Principal Investigator
Funding: NEUROPACE INC
via NATL INST OF HLTH NINDS
Jan 2021
ACTIVE
Central thalamic stimulation for traumatic brain injury
Role: Principal Investigator
Funding: CORNELL UNIV
via NATL INST OF HLTH NINDS
Jan 2021
– Mar 2024
Central thalamic deep brain stimulation to regulate arousal and cognition
Role: Principal Investigator
Funding: WEILL MED COLLEGE OF CORNELL UNIV
via NATL INST OF HLTH NINDS
Education
PhD Biomedical Engineering
2006
·
University of Utah, Salt Lake City, UT
Post-Doctoral Fellow, Department of Biomedical Engineering
2005
·
Cleveland Clinic Foundation, Cleveland, OH
Research Fellowship
2004
·
Friday Harbor Laboratories, Friday Harbor, WA
MS Electrical Engineering
1998
·
George Washington University, Washington, DC
BS Mechanical Engineering
1992
·
University of Maryland, Baltimore, MD
Contact Details
Emails:
- Business:
- butsonc@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100268
GAINESVILLE FL 32610 - Business Street:
-
3011 SW WILLISTON RD RM 1103
GAINESVILLE FL 32608