Diego E Rincon-Limas

Diego E Rincon-Limas, PhD

Associate Professor & University Term Professor

Business Phone: (352) 273-9689

About Diego E Rincon-Limas

Dr. Rincon-Limas received a bachelor degree on Biopharmaceutical Chemistry from the Autonomous University of Tamaulipas in Reynosa, Mexico. He also obtained a Master’s degree in Microbiology and a summa cum laude Ph.D. in Molecular Biology and Genetic Engineering at the Autonomous University of Nuevo Leon in Monterrey, Mexico. He then moved to Baylor College of Medicine in Houston to conduct his postdoctoral training in the Department of Human and Molecular Genetics, where he got training in Neurogenetics and Neurobiology. He got his first Faculty position in the Department of Neurology and the Mitchell Center for Neurodegenerative Disorders at the University of Texas Medical Branch in Galveston, and then moved to the University of Florida to join the Department of Neurology at the McKnight Brain Institute. He has a joint appointment in the Department of Neuroscience and is also a member of the UF Genetics Institute, the Center for Translational Research in Neurodegenerative Disease (CTRND), and the Center for Neurogenetics.


Exemplary Teacher Award
2018 · University of Florida College of Medicine
Exemplary Teacher Award
2017 · University of Florida College of Medicine
University Term Professorship Award
2017 · University of Florida

Research Profile

Neurodegenerative disorders, including Alzheimer’s disease, frontotemporal dementia, amyotrophic lateral sclerosis, Parkinson’s disease and prion diseases, are some of the most dreaded conditions in our society. These conditions affect millions of people worldwide, represent a huge and increasing burden on the health-care system, and constitute one of the major challenges of modern medicine. Unfortunately, the pathogenic mechanisms underlying these debilitating disorders are poorly understood and, therefore, there are no effective therapies to avoid their fatal outcome.

My laboratory focuses on the development and application of new technologies to define the molecular pathways leading to neurodegeneration and to identify potential therapeutic targets. To do so, we utilize the fruit fly Drosophila melanogaster to model molecular, biochemical and pathological aspects of human neurodegenerative conditions. This is achieved by disrupting homologous genes in Drosophila, or by expressing a human disease gene in this organism. Strikingly, the remarkable genetic conservation from flies to humans leads to neurological phenotypes that closely mimic the human disease. Once the model is validated, we apply a multidisciplinary approach combining Drosophila genetics, neurobiology, molecular biology, biochemistry, optogenetics and systems biology. My goal is to use this multidisciplinary effort to dissect unknown, fundamental events that mediate these devastating pathologies.


2018 The Journal of experimental medicine
2016 Proceedings of the National Academy of Sciences of the United States of America
2013 Journal of visualized experiments : JoVE
2011 Communicative & integrative biology
2010 The Journal of biological chemistry
1990 Nucleic acids research
1990 Nucleic acids research


Aug 2020 ACTIVE
Functional assessment of 1,500 human genes against coexistent Abeta and tau pathology in vivo
NATL INST OF HLTH NIA · Principal Investigator
Aug 2018 ACTIVE
Deconstructing and challenging TDP-43 proteinopathies: from FTLD/ALS to Alzheimers disease
NATL INST OF HLTH NIA · Principal Investigator
Jun 2018 ACTIVE
Exploring the unparalleled protection of RAF2 against Abeta42 and tau toxicity
NATL INST OF HLTH NIA · Principal Investigator
Sep 2017 – Jun 2020
Uncovering targets that block pathological interactions between Abeta and tau
NATL INST OF HLTH NIA · Principal Investigator
Feb 2017 – Sep 2019
Large-scale identification of genes that suppress concurrent Abeta42 and tau pathology in vivo
Apr 2016 – Mar 2019
Targeting nuclear transport dysfunction in TDP-43 proteinopathies
NATL INST OF HLTH NINDS · Principal Investigator
Nov 2015 ACTIVE
Optogenetic systems to regulate light-mediated transcription with spatiotemporal resolution
Jul 2014 – Jun 2017
Optogenetic modeling of primary and secondary CNS…….
NATL INST OF HLTH NINDS · Principal Investigator
Jul 2013 – Dec 2015
Engineering chaperones for extracellular amyloids
NATL INST OF HLTH · Principal Investigator

Contact Details

(352) 273-9689