Sub Subramony

Sub Subramony M.D.

PROF

Department: MD-NEUROMUSCULAR NEUROLOGY
Business Phone: (352) 273-5550

About Sub Subramony

Dr. S. H. Subramony was trained in Neurology and Electromyography/ Neuromuscular diseases at the Cleveland Clinic, Cleveland, OH. Subsequent to that, he was on the faculty at the University of Mississippi Medical Center from (from 1980 to 2007), where he was named the Billy Guyton Distinguished Professor of Neurology. Later, at University of Texas Medical Branch in Galveston where he was appointed the Charlotte Warmoth Professor of Neurology (2007 to 2009 ), before coming to University of Florida in 2009. He has directed the adult Muscular Dystrophy clinics and the Ataxia Clinic at UF since then.

Over the last 25 years, he has had an investigative interest in genetically determined neuromuscular disorders and hereditary ataxias. He was an active participant in many gene identification studies in these disorders and more recently has been focused on translational research to bring innovative therapies to these disorders. He has active collaborations with the Powell Gene Therapy center and the Center for Neurogenetics at UF allowing for bench to bedside translation. He is an active member of national study groups in Friedreich Ataxia, myotonic muscular dystrophy and spinocerebellar ataxias and site investigator for federally funded clinical research studies in all these disorders. In addition, he is the site investigator for many industry funded clinical trials in these diseases. Dr. Subramony is considered one of the world leading experts in these fields.

His clinical experience includes the management of patients with all types of neuromuscular diseases including ALS, myasthenia gravis, polymyositis, neuropathies and muscular dystrophies. Currently he focuses on genetic neuromuscular diseases and ataxias and offers treatment that includes electromyography, muscle biopsy when appropriate, appropriate genetic testing and referral to ancillary services such as physical, occupational and speech therapy and evaluation for mobility aids.

Honors & Awards

Ron Bartek award for promoting research in Friedirech Ataxia
2018 · Friedreich Ataxia Research Alliance
Billy Guyton Distinguished Professor
2004-2009 · University of Mississippi
Neuroscience Alumnus of the year
1992 · The Cleveland Clinic Foundation

Board Certifications

Neurology
American Board of Psychiatry and Neurology
American Board of Neurology, special certificate in Neuromuscular Medicine
American Baord of Psychiatry and Neurology

Clinical Profile

Specialties
  • Neurology
Areas of Interest
  • Amyotrophic lateral sclerosis (ALS)
  • Becker muscular dystrophy
  • Duchenne muscular dystrophy
  • Friedreich ataxia
  • Movement – uncoordinated
  • Muscular dystrophy
  • Myasthenia gravis
  • Myotonia congenita
  • Peripheral neuropathy

Research Profile

My key research interests include phenotypic characterization, phenotype-genotype correlations and pathogenic mechansims in genetically induced cerebellar ataxias and muscular dystrophies. In addition, I also am interested in developing assessment methods, biomarker discovery and therapeutic modalities for such diseases.

Publications

2013 Proceedings of the National Academy of Sciences of the United States of America
2013 Developmental Medicine and Child Neurology
2012 Journal of the Neurological Sciences

Grants

April 2019ACTIVE
Martino Research Fund-Social Cognition-ENDM1 Travel
UF FOU · Principal Investigator
April 2019ACTIVE
Butler Research Neurology-Social Cognition: Brain imaging and social cognition in myotonic dystrophy (DM) type 1
UF FOU · Principal Investigator
January 2019ACTIVE
Clinical Trial Readiness for SCA1 and SCA3
METHODIST HOSPITAL RESEARCH INSTITUTE · Principal Investigator
November 2018ACTIVE
Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type-1 (END-DM1) "Study"
VA COMMONWEALTH UNIV · Principal Investigator
June 2018 – May 2019
Collaborative Clinical Research Network in FA
FRIEDRICH'S ATAXIA RESEARCH ALLIANCE · Principal Investigator
June 2018ACTIVE
FARA-Supplemental Funding for AWD02770 FDA CHOP-Natural History of Friedreich Ataxia in Children
FRIEDRICH'S ATAXIA RESEARCH ALLIANCE · Principal Investigator
March 2018 – February 2023
Laryngeal adaptation in speech and swallowing
NATL INST OF HLTH NIDCD ·
January 2018 – December 2018
Clinical Trial Readiness for SCA1 and SCA3
METHODIST HOSPITAL RESEARCH INSTITUTE · Principal Investigator
September 2017ACTIVE
Natural history of Friedreich ataxia in children
CHILDRENS HOSP PHILADELPHIA · Principal Investigator
July 2017 – June 2018
2017 MDF Conference Travel Grant
MYOTONIC DYSTROPHY FOU · Principal Investigator
July 2017ACTIVE
Personalized dosing of dichloroacetate for the treatment of rare and common diseases
MEDOSOME BIOTEC ·
June 2017 – May 2018
Collaborative Clinical Research Network in Friedreich Ataxia
FRIEDRICH'S ATAXIA RESEARCH ALLIANCE · Principal Investigator
January 2017ACTIVE
Muscular Dystrophy Association Clinic Grants
MUSCULAR DYSTROPHY ASSO · Principal Investigator
June 2016 – August 2018
Development of Magnetic Resonance Imaging as an Endpoint in Myotonic Dystrophy Type 1
WYCK FOUNDATION ·
June 2016 – May 2017
Collaborative Clinical Research Network in Friedreich Ataxia (CCRN in FA)
FRIEDRICH'S ATAXIA RESEARCH ALLIANCE · Principal Investigator
January 2016 – December 2018
Myotonic Dystrophy Clinical Research Network
UNIV OF ROCHESTER · Principal Investigator
December 2015 – May 2017
Multicenter, Safety and Efficacy, Open-Label Extension Study of ACTIMMUNE? (interferon ?-1b) in Children and Young Adults with Friedreichs Ataxia
UNIV OF ROCHESTER · Principal Investigator
September 2015 – August 2018
Dysmetria and Motor Function in SCA: Mechanisms and Rehabilitation
NATL INST OF HLTH NINDS · Project Manager
September 2015ACTIVE
Partnership For Magnetic Resonance Spectroscopy Biomarker Development
UNIV OF MINNESOTA · Project Manager
July 2015 – June 2018
Pathophysiology of Upper and Lower Limb Motor Control in Spinocerebellar Ataxia
NATL INST OF HLTH NINDS · Project Manager
June 2015 – May 2016
Collaborative Clinical Research Network in Friedreich's Ataxia: Clinical Outcome Measures in Friedrich's Ataxia
FRIEDRICH'S ATAXIA RESEARCH ALLIANCE · Principal Investigator
March 2015 – May 2017
A Randomized, Multicenter, Double-blind, Placebo Controlled, Efficacy, Safety and Pharmacokinetic Study of ACTIMMUNE? (interferon Gamma-1b) in Children and Young Adults with Friedreichs Ataxia (STEADFAST)
UNIV OF ROCHESTER · Principal Investigator
December 2014ACTIVE
A Phase 2 Study of the Safety, Efficacy, and Pharmacodynamics of RTA 408 in the Treatment of Friedreichs Ataxia
TRIAL RUNNERS LLC · Principal Investigator
November 2014 – November 2017
A Phase 1/2a Blinded, Placebo-Controlled Study to Assess the Safety, Tolerability, and Dose-range Finding of Multiple Ascending Doses of ISIS 598769 Administered Subcutaneously to Adult Patients with Myotonic Dystrophy Type 1
INC RESEARCH INC · Principal Investigator
January 2014 – March 2016
DM1
MYOTONIC DYSTROPHY FOU · Principal Investigator
July 2007 – August 2016
CTSI
UF RESEARCH FOU · Project Manager
January 2001 – December 2016
MUSCULAR DYSTROPHY CLINIC
MUSCULAR DYSTROPHY ASSO · Principal Investigator

Education

1979
Fellowship – Clinical Neurophysiology
Cleveland Clinic
1978
Fellowship – Neurology
Cleveland Clinic
1975
Internship
MacNeal Hospital
1971
Bachelor of Medicine, Bachelor of Surgery
University of Delhi, Maulana Azad Medical College